Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/18596
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dc.contributor.authorCruz, Daniella Arêas Mendes da-
dc.contributor.authorLacerda, Leandra Linhares-
dc.contributor.authorSmaniotto, Salete-
dc.contributor.authorDardenne, Mireille-
dc.contributor.authorSavino, Wilson-
dc.date.accessioned2017-04-20T15:03:47Z-
dc.date.available2017-04-20T15:03:47Z-
dc.date.issued2012-
dc.identifier.citationCRUZ, Daniella Arêas Mendes da; et al. Semaphorins and neuropilins: new players in the neuroendocrine control of the intrathymic T-cell migration in humans. Esp. Psysiol, v.97, n.11, p.1146-1150, 2012.pt_BR
dc.identifier.issn0958-0670pt_BR
dc.identifier.urihttp://www.arca.fiocruz.br/handle/icict/18596-
dc.language.isoengpt_BR
dc.publisherWileypt_BR
dc.rightsrestricted accesspt_BR
dc.subject.otherMigração intratímica de células Tpt_BR
dc.subject.otherControle neuroendócrinopt_BR
dc.subject.otherNeuropilinaspt_BR
dc.subject.otherSemaforinaspt_BR
dc.titleSemaphorins and neuropilins: new players in the neuroendocrine control of the intrathymic T-cell migration in humanspt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1113/expphysiol.2011.061515-
dc.description.abstractenCell migration is a key event for proper intrathymic T-cell differentiation, and several ligand-receptor interactions contribute to the well-co ordinated movement of developing thymocytes within the thymic lobules. Herein we summarize recent data that place semaphorin 3A (Sema3A) and its receptor neuropilin 1 (NRP1) as further players in the physiological process of cell migration in the human thymus. These molecules, as well as class A plexins (necessary for the intracellular signalling transduction triggered by Sema3A-NRP1 ligation), are constitutively expressed by both developing thymocytes and components of the thymic microenvironment, including epithelial and dendritic cells. Functionally, Sema3A decreases the adhesion of human thymocytes on thymic epithelial cell monolayers and exerts per se a dose-dependent chemorepulsive effect on human thymocytes. Moreover, Sema3A inhibits chemoattractant migratory responses induced by other ligands, including fibronectin, laminin and CXCL12 (chemokine CXC motif ligand 12). These data should be placed in the context of the concept that migration of developing T cells is a multivectorial system, in which the resulting migration vector derives from a balance of several simultaneous and/or sequential ligand-receptor pair interactions. Accordingly, semaphorins and neuropilins can be considered as further players in the system.pt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.pt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.pt_BR
dc.creator.affilliationUniversidade Federal de Alagoas. Departamento de Morfologia. Maceió, AL, Brasilpt_BR
dc.creator.affilliationParis Descartes University. CNRS UMR8147. Paris, France.pt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.pt_BR
dc.subject.enintrathymic T-cell migrationpt_BR
dc.subject.enSemaphorinspt_BR
dc.subject.enneuropilinspt_BR
dc.subject.enneuroendocrine controlpt_BR
dc.identifier.eissn1469-445X-
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