Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/18589
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMachado, Marcus Paulo Ribeiro-
dc.contributor.authorRocha, Aletheia Moraes-
dc.contributor.authorOliveira, Lucas Felipe de-
dc.contributor.authorCuba, Marília Beatriz de-
dc.contributor.authorLoss, Igor de Oliveira-
dc.contributor.authorCastellano, Lucio Roberto-
dc.contributor.authorSilva, Marcus Vinicius-
dc.contributor.authorMachado, Juliana Reis-
dc.contributor.authorNascentes, Gabriel Antonio Nogueira-
dc.contributor.authorPaiva, Luciano Henrique-
dc.contributor.authorSavino, Wilson-
dc.contributor.authorJunior, Virmondes Rodrigues-
dc.contributor.authorBrum, Patricia Chakur-
dc.contributor.authorPrado, Vania Ferreira-
dc.contributor.authorPrado, Marco Antonio Maximo-
dc.contributor.authorSilva, Eliane Lages-
dc.contributor.authorMontano, Nicola-
dc.contributor.authorRamirez, Luis Eduardo-
dc.contributor.authorSilva, Valdo Jose Dias da-
dc.date.accessioned2017-04-20T13:10:43Z-
dc.date.available2017-04-20T13:10:43Z-
dc.date.issued2012-
dc.identifier.citationMACHADO, Marcus Paulo Ribeiro; et al. Autonomic nervous system modulation affects the inflammatory immune response in mice with acute Chagas disease. Exp Physiol, v.97. n.11, p 1186–1202, 2012.pt_BR
dc.identifier.issn0958-0670pt_BR
dc.identifier.urihttp://www.arca.fiocruz.br/handle/icict/18589-
dc.language.isoengpt_BR
dc.publisherWileypt_BR
dc.rightsrestricted accesspt_BR
dc.subject.otherDoença de Chagaspt_BR
dc.subject.otherRatospt_BR
dc.subject.otherSstema nervoso autônomopt_BR
dc.subject.otherResposta imunológica inflamatóriapt_BR
dc.subject.otherFase agudapt_BR
dc.titleAutonomic nervous system modulation affects the inflammatory immune response in mice with acute Chagas diseasept_BR
dc.typeArticlept_BR
dc.identifier.doi10.1113/expphysiol.2012.066431-
dc.description.abstractenThe aim of the present study was to evaluate the effects of changes to the autonomic nervous system in mice during the acute phase of Chagas disease, which is an infection caused by the parasite Trypanosoma cruzi. The following types of mice were inoculated with T. cruzi (CHG): wild-type (WT) and vesicular acetylcholine transporter knockdown (KDVAChT) C57BL/6j mice; wild-type non-treated (NT) FVB mice; FVB mice treated with pyridostigmine bromide (PYR) or salbutamol (SALB); and β(2)-adrenergic receptor knockout (KOβ2) FVB mice. During infection and at 18-21 days after infection (acute phase), the survival curves, parasitaemia, electrocardiograms, heart rate variability, autonomic tonus and histopathology of the animals were evaluated. Negative control groups were matched for age, genetic background and treatment. The KDVAChT-CHG mice exhibited a significant shift in the electrocardiographic, autonomic and histopathological profiles towards a greater inflammatory immune response that was associated with a reduction in blood and tissue parasitism. In contrast, the CHG-PYR mice manifested reduced myocardial inflammation and lower blood and tissue parasitism. Similar results were observed in CHG-SALB animals. Unexpectedly, the KOβ2-CHG mice exhibited less myocardial inflammation and higher blood and tissue parasitism, which were associated with reduced mortality. These findings could have been due to the increase in vagal tone observed in the KOβ2 mice, which rendered them more similar to the CHG-PYR animals. In conclusion, our results indicate a marked immunomodulatory role for the parasympathetic and sympathetic autonomic nervous systems, which inhibit both the inflammatory immune response and parasite clearance during the acute phase of experimental Chagas heart disease in mice.pt_BR
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas. Uberaba, MG, Brasil.pt_BR
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas. Uberaba, MG, Brasil.pt_BR
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas. Uberaba, MG, Brasil.pt_BR
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas. Uberaba, MG, Brasil.pt_BR
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas. Uberaba, MG, Brasil.pt_BR
dc.creator.affilliationUniversidade Federal da Paraíba. João Pessoa, PB, Brasil.pt_BR
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas. Uberaba, MG, Brasil.pt_BR
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas. Uberaba, MG, Brasil.pt_BR
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas. Uberaba, MG, Brasil.pt_BR
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas. Uberaba, MG, Brasil.pt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.pt_BR
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas. Uberaba, MG, Brasil.pt_BR
dc.creator.affilliationUniversidade de São Paulo. Escola de Educação Física e Esportes. São Paulo, SP, Brasil.pt_BR
dc.creator.affilliationUniversity of Western Ontario. Schulich School of Medicine & Dentistry. Robarts Research Institute. Molecular Brain Research Group. Ontario, Canada.pt_BR
dc.creator.affilliationUniversity of Western Ontario. Schulich School of Medicine & Dentistry. Robarts Research Institute. Molecular Brain Research Group. Ontario, Canada.pt_BR
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas. Uberaba, MG, Brasil.pt_BR
dc.creator.affilliationUniversity of Milan. Department of Clinical Sciences. Internal Medicine II, L. Sacco Hospital. Milano, Italy.pt_BR
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas. Uberaba, MG, Brasil.pt_BR
dc.subject.enAutonomic nervous systempt_BR
dc.subject.eninflammatory immune responsept_BR
dc.subject.enmicept_BR
dc.subject.enChagas Diseasept_BR
dc.subject.enacute phasept_BR
dc.identifier.eissn1469-445X-
Appears in Collections:IOC - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
wilson2_savino_etal_IOC_2012.pdf1.26 MBAdobe PDF    Request a copy


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.