Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/18182
Title: Why calpain inhibitors are interesting leading compounds to search for new therapeutic options to treat leishmaniasis?
Authors: Vidal, Vitor Ennes
Menna-Barreto, Rubem Figueiredo Sadock
Branquinha, Marta Helena
Santos, André Luis Souza dos
Levy, Claudia Masini D'Avila
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Estudos Integrados em Protozoologia. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
Universidade Federal do Rio de Janeiro. Laboratório de Investigação de Peptidases. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Laboratório de Investigação de Peptidases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Estudos Integrados em Protozoologia. Rio de Janeiro, RJ. Brasil.
Abstract: Leishmaniasis is a neglected disease, which needs improvements in drug development, mainly due to the toxicity, parasite resistance and low compliance of patients to treatment. Therefore, the development of new chemotherapeutic compounds is an urgent need. This opinion article will briefly highlight the feasible use of calpain inhibitors as leading compounds to search for new therapeutic options to treat leishmaniasis. The milestone of this approach is to take advantage on the myriad of inhibitors developed against calpains, some of which are in advanced clinical trials. The deregulated activity of these enzymes is associated with several pathologies, such as strokes, diabetes and Parkinson's disease, to name a few. In Leishmania, calpain upregulation has been associated to drug resistance and virulence. Whereas the difficulties in developing new drugs for neglected diseases are more economical than biotechnological, repurposing approach with compounds already approved for clinical use by the regulatory agencies can be an interesting shortcut to a successful chemotherapeutic treatment for leishmaniasis.
Keywords: Calpain inhibitors
leishmaniasis
repurpose approach
MDL28170
keywords: Leishmaniose
Inibidores de calpaína
Abordagem de reorientação
Issue Date: 2017
Publisher: Cambridge University Press
Citation: VIDAL, Vitor Ennes; et al. Why calpain inhibitors are interesting leading compounds to search for new therapeutic options to treat leishmaniasis?. Parasitology, v.114, n.2, p.117-123, Feb. 2017.
DOI: 10.1017/S003118201600189X
ISSN: 0031-1820
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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