Author | Sousa Neto, Ernesto Santos | |
Author | Cangussu, Maria Cristina Teixeira | |
Author | Gurgel, Clarissa Araújo | |
Author | Guimarães, Vanessa Sousa Nazaré | |
Author | Ramos, Eduardo Antônio Gonçalves | |
Author | Xavier, Flávia Caló Aquino | |
Author | Cury, Patrícia Ramos | |
Author | Carneiro Júnior, Braúlio | |
Author | Leonardi, Rosalia | |
Author | Santos, Jean Nunes Dos | |
Access date | 2017-03-21T13:08:08Z | |
Available date | 2017-03-21T13:08:08Z | |
Document date | 2016 | |
Citation | SOUZA NETO, E. S. et al. Interaction of stromal and microvascular components in keratocystic odontogenic tumors. Journal of Oral Pathology & Medicine, v. 45, p. 557–564, 2016. | pt_BR |
ISSN | 0904-2512 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/18093 | |
Language | eng | pt_BR |
Publisher | Wiley | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Angiogenese | pt_BR |
Subject in Portuguese | Células | pt_BR |
Subject in Portuguese | Queratocisto | pt_BR |
Subject in Portuguese | Linfangiogenese | pt_BR |
Subject in Portuguese | Macrófagos | pt_BR |
Subject in Portuguese | Miofibroblastos | pt_BR |
Title | Interaction of stromal and microvascular components in keratocystic odontogenic tumors | pt_BR |
Type | Article | pt_BR |
DOI | 10.1111/jop.12400 | |
Abstract | Little is known about the interaction of stromal components in odontogenic tumors. Thus, the aim of this study was to investigate mast cells (MCs), myofibroblasts, macrophages, and their possible association with angiogenesis and lymphangiogenesis in keratocystic odontogenic tumors (KCOTs). MATERIAL AND METHODS: Thirty cases of KCOTs
were included and analyzed by immunohistochemistry
for mast cell tryptase, a-SMA, CD34, CD163, and D240.
For comparative purpose, 15 radicular cysts (CRs) and 7
pericoronal follicles (PFs) were included.
RESULTS: There was an increase in MCs for RCs and this
difference was significant when they were compared to
KCOTS and PFs. A significant increase in the density of
MFs was observed for KCOTs when compared to RCs
and PFs (P = 0.00). No significant difference in CD163-
positive macrophages (P = 0.084) and CD34-positive vessels
(P = 0.244) densities was observed between KCOTs,
RCs, and PFs, although KCOTs showed a higher density
of all proteins. Significant difference in lymphatic vessel
density was observed for KCOTs when compared to RCs
and PFs (P = 0.00). Positive correlation was observed
between mast cell tryptase and CD34 in KCOTs
(P = 0.025).
CONCLUSIONS: A significant interaction between the
MC population and CD34-positive vessels in KCOTs
supported the hypothesis that MCs and blood vessels
contribute to the stromal scaffold of KCOT | pt_BR |
Affilliation | Federal University of Bahia. School of Dentistry. Dentistry and Health Postgraduate Program. Salvador, BA, Brazil | pt_BR |
Affilliation | Federal University of Bahia. School of Dentistry. Dentistry and Health Postgraduate Program. Salvador, BA, Brazil / Federal University of Bahia. School of Dentistry. Department Dental Public Health. Salvador, BA, Brazil | pt_BR |
Affilliation | Federal University of Bahia. School of Dentistry. Dentistry and Health Postgraduate Program. Salvador, BA, Brazil / Fiocruz. Oswaldo Cruz Foundation. Human Pathology Postgraduate Program. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fiocruz. Oswaldo Cruz Foundation. Human Pathology Postgraduate Program. Salvador, BA, Brazil | pt_BR |
Affilliation | Federal University of Bahia. School of Dentistry. Dentistry and Health Postgraduate Program. Salvador, BA, Brazil / Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, Brazil | pt_BR |
Affilliation | Federal University of Bahia. School of Dentistry. Dentistry and Health Postgraduate Program. Salvador, BA, Brazil / Federal University of Bahia. School of Dentistry. Division of Periodontics. Salvador, BA, Brazil | pt_BR |
Affilliation | Federal University of Bahia. School of Dentistry. Dentistry and Health Postgraduate Program. Salvador, BA, Brazil / Federal University of Bahia. School of Dentistry. Department of Oral and Maxillofacial Surgery. Salvador, BA, Brazil | pt_BR |
Affilliation | University of Catania. Department of Medical and Surgical Sciences. Catania, Italy | pt_BR |
Affilliation | Federal University of Bahia. School of Dentistry. Dentistry and Health Postgraduate Program. Salvador, BA, Brazil / Fiocruz. Oswaldo Cruz Foundation. Human Pathology Postgraduate Program. Salvador, BA, Brazil / Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, Brazil / | pt_BR |
Subject | Angiogenesis | pt_BR |
Subject | Cells | pt_BR |
Subject | Keratocyst | pt_BR |
Subject | Lymphangiogenesis | pt_BR |
Subject | Macrophages | pt_BR |
Subject | Myofibroblasts | pt_BR |