Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/18082
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dc.contributor.authorFigueiredo, Camylla Vilas Boas
dc.contributor.authorCarvalho, Magda Oliveira Seixas
dc.contributor.authorSantiago, Rayra Pereira
dc.contributor.authorSantana, Sânzio Silva
dc.contributor.authorOliveira, Rodrigo Mota de
dc.contributor.authorFiuza, Luciana Magalhães
dc.contributor.authorGuarda, Caroline Conceição da
dc.contributor.authorAleluia, Milena Magalhães
dc.contributor.authorNascimento, Valma Maria Lopes do
dc.contributor.authorLyra, Isa Menezes
dc.contributor.authorFerreira, Junia Raquel Dutra
dc.contributor.authorGoncalves, Marilda de Souza
dc.date.accessioned2017-03-20T17:41:54Z
dc.date.available2017-03-20T17:41:54Z
dc.date.issued2016
dc.identifier.citationFIGUEIREDO, C. V. B. et al. Leptin − 2548 G > A gene polymorphism is associated with lipids metabolism and TGF-β alteration in sickle cell disease. Meta Gene, v. 10, p. 27–31, 2016
dc.identifier.issn2214-5400
dc.identifier.urihttp://www.arca.fiocruz.br/handle/icict/18082
dc.description.sponsorshipBrazilian National Council of Research (CNPq) (3065427/2007-5 and 484457/2007-1) (M.S.G.); the Foundation of Research and Extension of Bahia (FAPESB) (1431040053063 and 9073/2007) (M.S.G.); and MCD/CNPq/MS-SCTIE-DECIT (409800/2006-6), (M.S.G.).
dc.language.isoeng
dc.publisherElsevier
dc.rightsopen access
dc.subject.otherDoença falciforme
dc.subject.otherLeptin
dc.subject.otherTGF-β
dc.subject.otherPolimorfismo gênico
dc.titleLeptin − 2548 G > A gene polymorphism is associated with lipids metabolism and TGF-β alteration in sickle cell disease
dc.typeArticle
dc.description.abstractenBackground: Leptin is a proteinwith regulatory role in several body systems such as the immune system, and energy balance. Given that patients with sickle cell disease (SCD) have changes in cellular immunity and lipid metabolism, it is important to conduct research aimed understand the role of leptin in the pathophysiology of SCD. Results:We studied 103 patients with SCD from Northeast of Brazil in a case-control study. The investigation of the leptin −2548 G N A polymorphism in SCD individuals shows the frequency of 60.20% (62/103) for the wild genotype (GG); 34.95% (36/103) for the heterozygous genotype (AG) and 4.85% (5/103) for the variant homozygote genotype (AA). In the healthy volunteers group the polymorphism investigation indicated the frequency of 58.24% (53/91) for the wild genotype (GG); 37.36% (34/91) for the heterozygous genotype (AG) and 4.40% (4/ 91) for the variant homozygote genotype (AA). The AA genotype was associated with increased levels of verylow- density lipoprotein cholesterol (VLDL-C) and triglycerides among SCD patients. Furthermore, the presence of allele A was associated with the highest levels of transforming growth factor beta (TGF-β) in SCD patients. Conclusion: The results suggest that the presence of the variant allele may influence the disturbances in lipidmetabolism and serum levels of TGF-β described in SCD patients.
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
dc.creator.affilliationComplexo Hospitalar Universitário Professor Edgard Santos. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
dc.creator.affilliationUniversidade Federal da Bahia. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
dc.creator.affilliationFundação de Hematologia e Hemoterapia da Bahia (HEMOBA). Salvador, BA, Brasil
dc.creator.affilliationComplexo Hospitalar Universitário Professor Edgard Santos. Salvador, BA, Brasil / Fundação de Hematologia e Hemoterapia da Bahia (HEMOBA). Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
dc.subject.enSickle cell disease
dc.subject.enLeptin
dc.subject.enTGF-β
dc.subject.enGene polymorphism
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