Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/18082
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dc.contributor.authorFigueiredo, Camylla Vilas Boas-
dc.contributor.authorCarvalho, Magda Oliveira Seixas-
dc.contributor.authorSantiago, Rayra Pereira-
dc.contributor.authorSantana, Sânzio Silva-
dc.contributor.authorOliveira, Rodrigo Mota de-
dc.contributor.authorFiuza, Luciana Magalhães-
dc.contributor.authorGuarda, Caroline Conceição da-
dc.contributor.authorAleluia, Milena Magalhães-
dc.contributor.authorNascimento, Valma Maria Lopes do-
dc.contributor.authorLyra, Isa Menezes-
dc.contributor.authorFerreira, Júnia Raquel Dutra-
dc.contributor.authorGoncalves, Marilda de Souza-
dc.date.accessioned2017-03-20T17:41:54Z-
dc.date.available2017-03-20T17:41:54Z-
dc.date.issued2016-
dc.identifier.citationFIGUEIREDO, C. V. B. et al. Leptin − 2548 G > A gene polymorphism is associated with lipids metabolism and TGF-β alteration in sickle cell disease. Meta Gene, v. 10, p. 27–31, 2016pt_BR
dc.identifier.issn2214-5400pt_BR
dc.identifier.urihttp://www.arca.fiocruz.br/handle/icict/18082-
dc.description.sponsorshipBrazilian National Council of Research (CNPq) (3065427/2007-5 and 484457/2007-1) (M.S.G.); the Foundation of Research and Extension of Bahia (FAPESB) (1431040053063 and 9073/2007) (M.S.G.); and MCD/CNPq/MS-SCTIE-DECIT (409800/2006-6), (M.S.G.).pt_BR
dc.language.isoengpt_BR
dc.publisherElsevierpt_BR
dc.rightsopen accesspt_BR
dc.subject.otherDoença falciformept_BR
dc.subject.otherLeptinpt_BR
dc.subject.otherTGF-βpt_BR
dc.subject.otherPolimorfismo gênicopt_BR
dc.titleLeptin − 2548 G > A gene polymorphism is associated with lipids metabolism and TGF-β alteration in sickle cell diseasept_BR
dc.typeArticlept_BR
dc.description.abstractenBackground: Leptin is a proteinwith regulatory role in several body systems such as the immune system, and energy balance. Given that patients with sickle cell disease (SCD) have changes in cellular immunity and lipid metabolism, it is important to conduct research aimed understand the role of leptin in the pathophysiology of SCD. Results:We studied 103 patients with SCD from Northeast of Brazil in a case-control study. The investigation of the leptin −2548 G N A polymorphism in SCD individuals shows the frequency of 60.20% (62/103) for the wild genotype (GG); 34.95% (36/103) for the heterozygous genotype (AG) and 4.85% (5/103) for the variant homozygote genotype (AA). In the healthy volunteers group the polymorphism investigation indicated the frequency of 58.24% (53/91) for the wild genotype (GG); 37.36% (34/91) for the heterozygous genotype (AG) and 4.40% (4/ 91) for the variant homozygote genotype (AA). The AA genotype was associated with increased levels of verylow- density lipoprotein cholesterol (VLDL-C) and triglycerides among SCD patients. Furthermore, the presence of allele A was associated with the highest levels of transforming growth factor beta (TGF-β) in SCD patients. Conclusion: The results suggest that the presence of the variant allele may influence the disturbances in lipidmetabolism and serum levels of TGF-β described in SCD patients.pt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasilpt_BR
dc.creator.affilliationComplexo Hospitalar Universitário Professor Edgard Santos. Salvador, BA, Brasilpt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasilpt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasilpt_BR
dc.creator.affilliationUniversidade Federal da Bahia. Salvador, BA, Brasilpt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasilpt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasilpt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasilpt_BR
dc.creator.affilliationFundação de Hematologia e Hemoterapia da Bahia (HEMOBA). Salvador, BA, Brasilpt_BR
dc.creator.affilliationComplexo Hospitalar Universitário Professor Edgard Santos. Salvador, BA, Brasil / Fundação de Hematologia e Hemoterapia da Bahia (HEMOBA). Salvador, BA, Brasilpt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasilpt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasilpt_BR
dc.subject.enSickle cell diseasept_BR
dc.subject.enLeptinpt_BR
dc.subject.enTGF-βpt_BR
dc.subject.enGene polymorphismpt_BR
Appears in Collections:IGM - Artigos de Periódicos

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