Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/18082
Title: Leptin − 2548 G > A gene polymorphism is associated with lipids metabolism and TGF-β alteration in sickle cell disease
Authors: Figueiredo, Camylla Vilas Boas
Carvalho, Magda Oliveira Seixas
Santiago, Rayra Pereira
Santana, Sânzio Silva
Oliveira, Rodrigo Mota de
Fiuza, Luciana Magalhães
Guarda, Caroline Conceição da
Aleluia, Milena Magalhães
Nascimento, Valma Maria Lopes do
Lyra, Isa Menezes
Ferreira, Junia Raquel Dutra
Goncalves, Marilda de Souza
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
Complexo Hospitalar Universitário Professor Edgard Santos. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
Universidade Federal da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
Fundação de Hematologia e Hemoterapia da Bahia (HEMOBA). Salvador, BA, Brasil
Complexo Hospitalar Universitário Professor Edgard Santos. Salvador, BA, Brasil / Fundação de Hematologia e Hemoterapia da Bahia (HEMOBA). Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
Abstract: Background: Leptin is a proteinwith regulatory role in several body systems such as the immune system, and energy balance. Given that patients with sickle cell disease (SCD) have changes in cellular immunity and lipid metabolism, it is important to conduct research aimed understand the role of leptin in the pathophysiology of SCD. Results:We studied 103 patients with SCD from Northeast of Brazil in a case-control study. The investigation of the leptin −2548 G N A polymorphism in SCD individuals shows the frequency of 60.20% (62/103) for the wild genotype (GG); 34.95% (36/103) for the heterozygous genotype (AG) and 4.85% (5/103) for the variant homozygote genotype (AA). In the healthy volunteers group the polymorphism investigation indicated the frequency of 58.24% (53/91) for the wild genotype (GG); 37.36% (34/91) for the heterozygous genotype (AG) and 4.40% (4/ 91) for the variant homozygote genotype (AA). The AA genotype was associated with increased levels of verylow- density lipoprotein cholesterol (VLDL-C) and triglycerides among SCD patients. Furthermore, the presence of allele A was associated with the highest levels of transforming growth factor beta (TGF-β) in SCD patients. Conclusion: The results suggest that the presence of the variant allele may influence the disturbances in lipidmetabolism and serum levels of TGF-β described in SCD patients.
Keywords: Sickle cell disease
Leptin
TGF-β
Gene polymorphism
keywords: Doença falciforme
Leptin
TGF-β
Polimorfismo gênico
Issue Date: 2016
Publisher: Elsevier
Citation: FIGUEIREDO, C. V. B. et al. Leptin − 2548 G > A gene polymorphism is associated with lipids metabolism and TGF-β alteration in sickle cell disease. Meta Gene, v. 10, p. 27–31, 2016
ISSN: 2214-5400
Copyright: open access
Appears in Collections:IGM - Artigos de Periódicos

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