Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/18080
Title: New "light" for one-world approach toward safe and effective control of animal diseases and insect vectors from leishmaniac perspectives
Authors: Chang, Kwang Poo
Kolli, Bala K
New Light Group, Group
Affilliation: Chicago Medical School. Department of Microbiology, Immunology / Rosalind Franklin University of Medicine and Science. North Chicago, IL, EUA
Chicago Medical School. Department of Microbiology, Immunology / Rosalind Franklin University of Medicine and Science. North Chicago, IL, EUA
Light Group - Múltipla - ver em Notas
Abstract: Light is known to excite photosensitizers (PS) to produce cytotoxic reactive oxygen species (ROS) in the presence of oxygen. This modality is attractive for designing control measures against animal diseases and pests. Many PS have a proven safety record. Also, the ROS cytotoxicity selects no resistant mutants, unlike other drugs and pesticides. Photodynamic therapy (PDT) refers to the use of PS as light activable tumoricides, microbicides and pesticides in medicine and agriculture.Here we describe "photodynamic vaccination" (PDV) that uses PDT-inactivation of parasites, i.e. Leishmania as whole-cell vaccines against leishmaniasis, and as a universal carrier to deliver transgenic add-on vaccines against other infectious and malignant diseases. The efficacy of Leishmania for vaccine delivery makes use of their inherent attributes to parasitize antigen (vaccine)-presenting cells. Inactivation of Leishmania by PDT provides safety for their use. This is accomplished in two different ways: (i) chemical engineering of PS to enhance their uptake, e.g. Si-phthalocyanines; and (ii) transgenic approach to render Leishmania inducible for porphyrinogenesis. Three different schemes of Leishmania-based PDV are presented diagrammatically to depict the cellular events resulting in cell-mediated immunity, as seen experimentally against leishmaniasis and Leishmania-delivered antigen in vitro and in vivo. Safety versus efficacy evaluations are under way for PDT-inactivated Leishmania, including those further processed to facilitate their storage and transport. Leishmania transfected to express cancer and viral vaccine candidates are being prepared accordingly for experimental trials.We have begun to examine PS-mediated photodynamic insecticides (PDI). Mosquito cells take up rose bengal/cyanosine, rendering them light-sensitive to undergo disintegration in vitro, thereby providing a cellular basis for the larvicidal activity seen by the same treatments. Ineffectiveness of phthalocyanines and porphyrins for PDI underscores its requirement for different PS. Differential uptake of PS by insect versus other cells to account for this difference is under study.The ongoing work is patterned after the one-world approach by enlisting the participation of experts in medicinal chemistry, cell/molecular biology, immunology, parasitology, entomology, cancer research, tropical medicine and veterinary medicine. The availability of multidisciplinary expertise is indispensable for implementation of the necessary studies to move the project toward product development.
Keywords: Photosensitizers
Leishmania
Mosquito
Photodynamic therapy
Photodynamic vaccination
Photodynamic insecticide
keywords: Fotossensibilizadores
Leishmania
Mosquito
Terapia fotodinâmica
Vacinação fotodinâmica
Inseticida fotodinâmico
Issue Date: 2016
Publisher: BioMed Central
Citation: CHAN, K. P.; KOLLI, B. K. et al. New "light" for one-world approach toward safe and effective control of animal diseases and insect vectors from leishmaniac perspectives. Parasites & Vectors, v. 9, p. 396, 2016.
Description: Camila Indiani de Oliveira. FIOCRUZ. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brazil
Ramesh B. Batchu, PhD, Director, Division of Surgical Oncology & Developmental, Therapeutics, Associate Professor, The Michael and Marian Ilitch Department of Surgery, Wayne State University, 4646 John R Road, Detroit, MI 48201, USA. rameshbabu.batchu@gmail.com Hui-Wen (Winni) Chen, DVM, PhD (陳慧文), Assistant Professor, Department of Veterinary Medicine, National Taiwan University, 1 Sec. 4 Roosevelt Rd., Taipei, 10617 Taiwan. winnichen@ntu.edu.tw Larry Ming C. Chow, ScD (周銘祥), Associate Head and Professor, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hong Kong. larry.chow@polyu.edu.hk Robert Elliott, MD/Jonathan F. Head, PhD, Elliott Mastology Center, 541 Shadows Lane, Baton Rouge, LA 70806, USA. relliott@eehbreastca.com Chia-Kwung Fan PhD (范家堃), Professor and Chairman, Department of Molecular Parasitology and Tropical Diseases, School of Medicine and Center for International Tropical Medicine, College of Medicine, 250 Wu-Xing Street, Taipei Medical University, Taipei, Taiwan. tedfan@tmu.edu.tw Chen-Hsiung Hung, PhD (洪政雄), Investigator and Vice Director, Institute of Chemistry, Academia Sinica, 128, Sec. 2, Academia Road,, Nankang, Taipei, Taiwan 11529. chhung@gate.sinica.edu.tw Dar-Der Ji, PhD (嵇達德), Associate Professor, Department of Tropical Medicine/International Health Programs, National Yang-Ming University, Beitou, Taipei 112, Taiwan. ddji@ym.edu.tw Zhao-Rong Lun, PhD (伦照荣), Professor & Director, Center for Parasitic Organisms, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, P.R. China. lsslzr@mail.sysu.edu.cn Laura Manna, PhD, DVM, School of Veterinary Medicine and Animal Productions, University of Naples, Federico II, Naples, Italy. laumanna@unina.it Yoshitsugu Matsumoto, DVM, PhD, Professor, Laboratory of Molecular Immunology, School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1-1-1, Tokyo, Japan 113-8657 aysmatsu@mail.ecc.u-tokyo.ac.jp Dennis KP Ng, DPhil (吳基培), Professor, Department of Chemistry, Chinese University of Hong Kong, Sha Tin, N. T., Hong Kong. dkpn@cuhk.edu.hk Camila I. de Oliveira PhD/Sayonara Melo, Centro de Pesquisas Gonçalo Moniz. FIOCRUZ, R. Waldemar, Falcão, 121 Candeal, Salvador- BA -40296-710, Brazil. camila@bahia.fiocruz.br Yusuf Ozbel, MD, Professor, Ege University Faculty of Medicine, Department of Parasitology, 35100 Bornova, Izmir,TURKEY. yusuf.ozbel@gmail.com Ahmet Özbilgin. PhD, Professor, Celal Bayar Üniversitesi, Tip Fakültesi Parazitoloji A.D, Dekanlik Binasi Uncubozköy, 45030, Manisa, Türkiye. a.ozbilgin@yahoo.com Joseph Reynolds, PhD, Department of Microbiology/Immunology, Chicago Medical School/RFUMS, N Chicago, IL 60064, USA. joseph.reynolds@rosalindfranklin.edu Chizu Sanjoba, PhD, Laboratory of Molecular Immunology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1Yayoi, Bunkyo-ku, Tokyo 113-8657 Japan. asanjoba@mail.ecc.u-tokyo.ac.jp, Shin-Hong Shiao, PhD (蕭信宏), Assistant Professor, Department of Parasitology, Institute of Microbiology, School of Medicine, National Taiwan University, Taipei, Taiwan. shshiao@ntu.edu.tw Nang-Yao Shih, PhD (施能耀), Associate Investigator, National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan. jshih@nhri.org.tw Chi-Wei Tsai, PhD (蔡志偉), Associate Professor, Department of Entomology, College of Natural Resources and Agriculture, National Taiwan University, 1 Sec. 4 Roosevelt Rd., Taipei, 10617 Taiwan. chiwei@ntu.edu.tw Maria da Graça H. Vicente, PhD, Distinguished Professor, Department of Chemistry, 249 Chemistry and Materials Building, Highland Rd, Louisiana State University, Baton Rouge, LA 70803, USA. vicente@lsu.edu Petr Volf, PhD, Professor, Department of Parasitology, Faculty of Science, Charles University Vinicna 7, 128 44 Praha 2, Czech Republic. volf@cesnet.cz Yueh-Lung Wu, PhD (吳岳隆), Assistant Professor, Department of Entomology, College of Natural Resources and Agriculture, National Taiwan University, 1 Sec. 4 Roosevelt Rd., Taipei, 10617 Taiwan. runwu@ntu.edu.tw Chao-Lan Yu, PhD (郁兆蘭), Professor, Department of Biomedical Sciences, Chang Gung University, No. 259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 33302, Taiwan. clyu@mail.cgu.edu.tw Xiao-Nong Zhou, PhD (周晓农),Professor and Director, National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, 207 Rui Jin Er Road, Shanghai 200025, P.R. China. zhouxn1@chinacdc.cn; ipdzhouxn@sh163.net
DOI: 10.1186/s13071-016-1674-3
ISSN: 1756-3305
Copyright: open access
Appears in Collections:IGM - Artigos de Periódicos

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