Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/18076
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dc.contributor.authorDória, Grace Anne Azevedo
dc.contributor.authorMenezes, Paula dos Passos
dc.contributor.authorLima, Bruno S
dc.contributor.authorVasconcelos, Bruno S
dc.contributor.authorSilva, Francilene Amaral da
dc.contributor.authorHenriques, Raíssa Melo
dc.contributor.authorMelo, Marcélia Garcez Dória de
dc.contributor.authorAlves, Ângela V F
dc.contributor.authorMoraes, Manoel O
dc.contributor.authorPessoa, Cláudia Ó
dc.contributor.authorCarvalho, Adriana A
dc.contributor.authorPrata, Ana Paula do Nascimento
dc.contributor.authorAlbuquerque Junior, Ricardo Luiz Cavalcanti de
dc.contributor.authorVerde, Isabel Bezerra Lima
dc.contributor.authorQuintans Júnior, Lucindo José
dc.contributor.authorBezerra, Daniel Pereira
dc.contributor.authorNogueira, Paulo C L
dc.contributor.authorAraujo, Adriano A S
dc.date.accessioned2017-03-17T17:46:36Z
dc.date.available2017-03-17T17:46:36Z
dc.date.issued2016
dc.identifier.citationDÓRIA, G. A. A. et al. In vivo antitumor effect, induction of apoptosis and safety of Remirea maritima Aubl. (Cyperaceae) extracts. Phytomedicine, v. 23, p. 914–922, 2016.
dc.identifier.issn0944-7113
dc.identifier.urihttp://www.arca.fiocruz.br/handle/icict/18076
dc.description.sponsorshipCNPq/MCTI
dc.language.isoeng
dc.publisherElsevier
dc.rightsopen access
dc.subject.otherRemirea maritima
dc.subject.otherAntitumor
dc.subject.otherSarcoma 180
dc.subject.otherApoptose
dc.subject.otherToxicidade
dc.subject.otherTúnel
dc.titleIn vivo antitumor effect, induction of apoptosis and safety of Remirea maritima Aubl. (Cyperaceae) extracts
dc.typeArticle
dc.identifier.doi10.1016/j.phymed.2016.05.001
dc.description.abstractenRemirea maritima has been widely used in the treatment of diarrhea, kidney disease, and high fever and for therapeutic purposes, such as an analgesic and anti-inflammatory. However, few scientific research studies on its medicinal properties have been reported. Purpose: The present study aimed to investigate the anticancer potential of aqueous extract (AE), 40% hydroalcoholic extracts (40HA) and 70% (70HA) from R. maritima in experimental models and to identify its phytochemical compounds. Methods: The chemical composition of AE, 40HA and 70HA was assessed by HPLC-DAD and ESI-IT-MS/MS . In vitro activity was determined on cultured tumor cell, NCI-H385N (Broncho-alveolar carcinoma), OVCAR- 8 (Ovarian carcinoma) and PC-3 M (prostate carcinoma) by the MTT assay, and the in vivo antitumor activity was assessed in Sarcoma 180-bearing mice. Toxicological parameters were also evaluated as well as the humoral immune response. Results: Among the aqueous and hydroalcoholic extracts of R. maritima , only 40HA showed in vitro bi- ological effect potential, presenting IC 50 values of 27.08, 46.62 and > 50 μg/ml for OVCAR-8, NCI-H385M and PC-3 M cells lines, respectively. Regarding chemical composition, a mixture of isovitexin-2 - O - β-D- glucopyranoside, vitexin-2 - O - β-D-glucopyranoside, luteolin-7- O -glucuronide and 1- O -(E)-caffeoyl- β-D- glucose were identified as the major phytochemical compounds of the extracts. In the in vivo study, the tumor inhibition rates were 57.16–62.57% at doses of 25 mg/kg and 50 mg/kg, respectively, and the tu- mor morphology presented increasing numbers of apoptotic cells. Additionally, 40HA also demonstrated significantly increased of OVA-specific total Ig. Conclusions: 40HA exhibited in vitro and in vivo anticancer properties without substantial toxicity that could be associated with its immunostimulating properties.
dc.creator.affilliationFederal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, Brazil
dc.creator.affilliationFederal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, Brazil
dc.creator.affilliationFederal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, Brazil
dc.creator.affilliationFederal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, Brazil
dc.creator.affilliationFederal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, Brazil
dc.creator.affilliationFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil
dc.creator.affilliationFederal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, Brazil
dc.creator.affilliationTiradentes University. Institute of Technology and Research. Aracaju, SE, Brazil
dc.creator.affilliationFederal University of Ceará. School of Medicine. Department of Physiology and Pharmacology. Fortaleza, CE, Brazil
dc.creator.affilliationFederal University of Ceará. School of Medicine. Department of Physiology and Pharmacology. Fortaleza, CE, Brazil
dc.creator.affilliationFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil
dc.creator.affilliationFederal University of Sergipe. Department of Biology. São Cristóvão, SE, Brazil
dc.creator.affilliationTiradentes University. Institute of Technology and Research. Aracaju, SE, Brazil
dc.creator.affilliationTiradentes University. Institute of Technology and Research. Aracaju, SE, Brazil
dc.creator.affilliationFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFederal University of Sergipe. Department of Chemistry. São Cristóvão, SE, Brazil
dc.subject.enRemirea maritima
dc.subject.enAntitumor
dc.subject.enSarcoma 180
dc.subject.enApoptosis
dc.subject.enToxicity
dc.subject.enTunel
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