Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/18076
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dc.contributor.authorDória, Grace Anne Azevedo-
dc.contributor.authorMenezes, Paula dos Passos-
dc.contributor.authorLima, Bruno S-
dc.contributor.authorVasconcelos, Bruno S-
dc.contributor.authorSilva, Francilene Amaral da-
dc.contributor.authorHenriques, Raíssa Melo-
dc.contributor.authorMelo, Marcélia Garcez Dória de-
dc.contributor.authorAlves, Ângela V F-
dc.contributor.authorMoraes, Manoel O-
dc.contributor.authorPessoa, Cláudia Ó-
dc.contributor.authorCarvalho, Adriana A-
dc.contributor.authorPrata, Ana Paula do Nascimento-
dc.contributor.authorAlbuquerque Junior, Ricardo Luiz Cavalcanti de-
dc.contributor.authorVerde, Isabel Bezerra Lima-
dc.contributor.authorQuintans Júnior, Lucindo José-
dc.contributor.authorBezerra, Daniel Pereira-
dc.contributor.authorNogueira, Paulo C L-
dc.contributor.authorAraujo, Adriano A S-
dc.date.accessioned2017-03-17T17:46:36Z-
dc.date.available2017-03-17T17:46:36Z-
dc.date.issued2016-
dc.identifier.citationDÓRIA, G. A. A. et al. In vivo antitumor effect, induction of apoptosis and safety of Remirea maritima Aubl. (Cyperaceae) extracts. Phytomedicine, v. 23, p. 914–922, 2016.pt_BR
dc.identifier.issn0944-7113pt_BR
dc.identifier.urihttp://www.arca.fiocruz.br/handle/icict/18076-
dc.description.sponsorshipCNPq/MCTIpt_BR
dc.language.isoengpt_BR
dc.publisherElsevierpt_BR
dc.rightsopen accesspt_BR
dc.subject.otherRemirea maritimapt_BR
dc.subject.otherAntitumorpt_BR
dc.subject.otherSarcoma 180pt_BR
dc.subject.otherApoptosept_BR
dc.subject.otherToxicidadept_BR
dc.subject.otherTúnelpt_BR
dc.titleIn vivo antitumor effect, induction of apoptosis and safety of Remirea maritima Aubl. (Cyperaceae) extractspt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.phymed.2016.05.001-
dc.description.abstractenRemirea maritima has been widely used in the treatment of diarrhea, kidney disease, and high fever and for therapeutic purposes, such as an analgesic and anti-inflammatory. However, few scientific research studies on its medicinal properties have been reported. Purpose: The present study aimed to investigate the anticancer potential of aqueous extract (AE), 40% hydroalcoholic extracts (40HA) and 70% (70HA) from R. maritima in experimental models and to identify its phytochemical compounds. Methods: The chemical composition of AE, 40HA and 70HA was assessed by HPLC-DAD and ESI-IT-MS/MS . In vitro activity was determined on cultured tumor cell, NCI-H385N (Broncho-alveolar carcinoma), OVCAR- 8 (Ovarian carcinoma) and PC-3 M (prostate carcinoma) by the MTT assay, and the in vivo antitumor activity was assessed in Sarcoma 180-bearing mice. Toxicological parameters were also evaluated as well as the humoral immune response. Results: Among the aqueous and hydroalcoholic extracts of R. maritima , only 40HA showed in vitro bi- ological effect potential, presenting IC 50 values of 27.08, 46.62 and > 50 μg/ml for OVCAR-8, NCI-H385M and PC-3 M cells lines, respectively. Regarding chemical composition, a mixture of isovitexin-2 - O - β-D- glucopyranoside, vitexin-2 - O - β-D-glucopyranoside, luteolin-7- O -glucuronide and 1- O -(E)-caffeoyl- β-D- glucose were identified as the major phytochemical compounds of the extracts. In the in vivo study, the tumor inhibition rates were 57.16–62.57% at doses of 25 mg/kg and 50 mg/kg, respectively, and the tu- mor morphology presented increasing numbers of apoptotic cells. Additionally, 40HA also demonstrated significantly increased of OVA-specific total Ig. Conclusions: 40HA exhibited in vitro and in vivo anticancer properties without substantial toxicity that could be associated with its immunostimulating properties.pt_BR
dc.creator.affilliationFederal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, Brazilpt_BR
dc.creator.affilliationFederal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, Brazilpt_BR
dc.creator.affilliationFederal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, Brazilpt_BR
dc.creator.affilliationFederal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, Brazilpt_BR
dc.creator.affilliationFederal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, Brazilpt_BR
dc.creator.affilliationFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazilpt_BR
dc.creator.affilliationFederal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, Brazilpt_BR
dc.creator.affilliationTiradentes University. Institute of Technology and Research. Aracaju, SE, Brazilpt_BR
dc.creator.affilliationFederal University of Ceará. School of Medicine. Department of Physiology and Pharmacology. Fortaleza, CE, Brazilpt_BR
dc.creator.affilliationFederal University of Ceará. School of Medicine. Department of Physiology and Pharmacology. Fortaleza, CE, Brazilpt_BR
dc.creator.affilliationFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazilpt_BR
dc.creator.affilliationFederal University of Sergipe. Department of Biology. São Cristóvão, SE, Brazilpt_BR
dc.creator.affilliationTiradentes University. Institute of Technology and Research. Aracaju, SE, Brazilpt_BR
dc.creator.affilliationTiradentes University. Institute of Technology and Research. Aracaju, SE, Brazilpt_BR
dc.creator.affilliationFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazilpt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasilpt_BR
dc.creator.affilliationFederal University of Sergipe. Department of Chemistry. São Cristóvão, SE, Brazilpt_BR
dc.subject.enRemirea maritimapt_BR
dc.subject.enAntitumorpt_BR
dc.subject.enSarcoma 180pt_BR
dc.subject.enApoptosispt_BR
dc.subject.enToxicitypt_BR
dc.subject.enTunelpt_BR
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