Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/18072
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dc.contributor.authorBouzas, Maiara Lanna Souza Bacelar-
dc.contributor.authorOliveira, Juliana R-
dc.contributor.authorFukutani, Kiyoshi Ferreira-
dc.contributor.authorBorges, Igor Carmo-
dc.contributor.authorBarral, Aldina Maria Prado-
dc.contributor.authorGucht, Winke Van der-
dc.contributor.authorWollants, Elke-
dc.contributor.authorVan Ranst, Marc-
dc.contributor.authorOliveira, Camila Indiani de-
dc.contributor.authorVan Weyenbergh, Johan Jozef Rosa Maria-
dc.contributor.authorCarvalho, Cristiana Maria Costa Nascimento de-
dc.contributor.authorThe Acute Respiratory Infection, Wheeze Study Group Phase I, II-
dc.date.accessioned2017-03-17T14:22:59Z-
dc.date.available2017-03-17T14:22:59Z-
dc.date.issued2016-
dc.identifier.citationBOUZAS, M. L. S. B. et al. Respiratory syncytial virus a and b display different temporal patterns in a 4-year prospective cross-sectional study among children with acute respiratory infection in a tropical city. Medicine, v. 95, p. 41, 2016.pt_BR
dc.identifier.issn0025-7974pt_BR
dc.identifier.urihttp://www.arca.fiocruz.br/handle/icict/18072-
dc.description.sponsorshipBahia State Agency for Research Funding (FAPESB) [grant numbers APP0045/2009 and PNX0019/2009]. FAPESB had no role in study design, data collection, data analysis, data interpretation, or writing of the report.pt_BR
dc.language.isoengpt_BR
dc.publisherWillams & Wilkinspt_BR
dc.rightsopen accesspt_BR
dc.subject.otherInfecção respiratória agudapt_BR
dc.subject.otherImunoprofilaxiapt_BR
dc.subject.otherRSVpt_BR
dc.subject.otherRSVApt_BR
dc.subject.otherRSVBpt_BR
dc.subject.otherSazonalidadept_BR
dc.titleRespiratory syncytial virus a and b display different temporal patterns in a 4-year prospective cross-sectional study among children with acute respiratory infection in a tropical citypt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1097/MD.0000000000005142-
dc.description.abstractenRespiratory syncytial virus (RSV) is one of the most common etiological agents of childhood respiratory infections globally. Information on seasonality of different antigenic groups is scarce. We aimed to describe the frequency, seasonality, and age of children infected by RSV antigenic groups A (RSVA) and B (RSVB) among children with ARI in a 4-year period.Children (6-23 months old) with respiratory infection for ≤7 days were enrolled in a prospective cross-sectional study, from September, 2009 to October, 2013, in Salvador, in a tropical region of Brazil. Upon recruitment, demographic, clinical data, and nasopharyngeal aspirates (NPA) were collected. A multiplex quantitative real-time polymerase chain reaction (RT-PCR) with a group-specific primer and probeset for RSVA and RSVB was used. Seasonal distribution of infection by RSV different antigenic groups was evaluated by Prais-Wisten regression.Of 560 cases, the mean age was 11.4 ± 4.5 months and there were 287 (51.3%) girls. Overall, RSV was detected in 139 (24.8%; 95% CI: 21.4%-28.5%) cases, RSVA in 74 (13.2%; 95% CI: 10.6%-16.2%) cases, and RSVB in 67 (12.0%; 95% CI: 9.5%-14.9%) cases. Two (0.4%; 95% CI: 0.06%-1.2%) cases had coinfection. RSVA frequency was 9.6%, 18.4%, 21.6%, and 3.1% in 2010, 2011, 2012, and 2013, respectively. RSVB frequency was 19.2%, 0.7%, 1.4%, and 35.4% in the same years. RSVA was more frequently found from August to January than February to July (18.2% vs. 6.4%, P < 0.001). RSVB was more frequently found (P < 0.001) between March and June (36.0%) than July to October (1.0%) or November to February (1.6%). RSVB infection showed seasonal distribution and positive association with humidity (P = 0.02) whereas RSVA did not. RSVA was more common among children ≥1-year-old (17.8% vs. 1.8%; P = 0.02), as opposed to RSVB (11.5% vs. 12.2%; P = 0.8).One quarter of patients had RSV infection. RSVA compromised more frequently children aged ≥1 year. RSVA predominated in 2011 and 2012 whereas RSVB predominated in 2010 and 2013. In regard to months, RSVA was more frequent from August to January whereas RSVB was more often detected between March and June. Markedly different monthly as well as yearly patterns for RSVA and RSVB reveal independent RSV antigenic groups' epidemics.pt_BR
dc.creator.affilliationFederal University of Bahia. School of Medicine. Salvador, BA, Brazilpt_BR
dc.creator.affilliationFederal University of Bahia. School of Medicine. Salvador, BA, Brazilpt_BR
dc.creator.affilliationFederal University of Bahia. School of Medicine. Salvador, BA, Brazilpt_BR
dc.creator.affilliationFederal University of Bahia. School of Medicine. Salvador, BA, Brazilpt_BR
dc.creator.affilliationFederal University of Bahia. School of Medicine., Salvador, BA, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Department of Pathology. Salvador, BA, Brazipt_BR
dc.creator.affilliationRega Institute for Medical Research. Laboratory for Clinical and Epidemiological Virology. Department of Microbiology and Immunology. KU, Leuven, Belgiumpt_BR
dc.creator.affilliationRega Institute for Medical Research. Laboratory for Clinical and Epidemiological Virology. Department of Microbiology and Immunology. KU, Leuven, Belgiumpt_BR
dc.creator.affilliationRega Institute for Medical Research. Laboratory for Clinical and Epidemiological Virology. Department of Microbiology and Immunology. KU, Leuven, Belgiumpt_BR
dc.creator.affilliationFederal University of Bahia. School of Medicine. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasilpt_BR
dc.creator.affilliationRega Institute for Medical Research. Laboratory for Clinical and Epidemiological Virology. Department of Microbiology and Immunology. KU, Leuven, Belgiumpt_BR
dc.creator.affilliationFederal University of Bahia. School of Medicine. Salvador, BA, Brazil / Federal University of Bahia. School of Medicine. Department of Pediatrics. Salvador, BA, Brazilpt_BR
dc.subject.enAcute respiratory infectionpt_BR
dc.subject.enImmunoprophylaxispt_BR
dc.subject.enPalivizumabpt_BR
dc.subject.enRSVpt_BR
dc.subject.enRSVApt_BR
dc.subject.enRSVBpt_BR
dc.subject.enSeasonalitypt_BR
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