Author | Menezes, Juliana Perrone de | |
Author | Saraiva, Elvira Maria | |
Author | Azevedo, Bruno da Rocha | |
Access date | 2017-03-16T16:57:00Z | |
Available date | 2017-03-16T16:57:00Z | |
Document date | 2016 | |
Citation | MENEZES, J. P.; SARAIVA, E. M.; AZEVEDO, B. R. The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis. Parasites & Vectors, v. 9, p. 264, 2016. | pt_BR |
ISSN | 1756-3305 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/18062 | |
Sponsorship | CAPES-MEC, CNPq, Programa Ciências Sem Fronteiras, CPqGM-FIOCRUZ, and FAPERJ for the financial support. BRA is a Young Talent Fellow from Science Without Frontiers Program, CAPES-MEC
(CsF/BJT – 88887.091752/2014-00) | pt_BR |
Language | eng | pt_BR |
Publisher | BioMed Central | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Leishmania | pt_BR |
Subject in Portuguese | Matriz extracelular | pt_BR |
Subject in Portuguese | Macrófagos | pt_BR |
Subject in Portuguese | Neutrófilos | pt_BR |
Title | The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis | pt_BR |
Type | Article | pt_BR |
DOI | 10.1186/s13071-016-1540-3 | |
Abstract | Leishmania spp., the causative agents of leishmaniasis, are intracellular parasites, transmitted to humans via the bite of their sand fly vectors. Once inoculated, the promastigotes are exposed to the dermis, which is composed of extracellular matrix (ECM), growth factors and its resident cells. Promastigote forms are phagocytosed by macrophages recruited to the site of the sand fly bite, either directly or after interaction with neutrophils. Since Leishmania is an intracellular parasite, its interaction with the host ECM has been neglected as well as the immediate steps after the sand fly bite. However, promastigotes must overcome the obstacles presented by the dermis ECM in order to establish the infection. Thus, the study of the interaction between Leishmania promastigotes and ECM components as well as the earliest stages of infection are important steps to understand the establishment of the disease, and could contribute in the future to new drug developments towards leishmaniasis. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Departamento de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / The University of Texas Southwestern Medical Center. Harry Hines Boulevard. Dallas, TX, USA | pt_BR |
Subject | Leishmania | pt_BR |
Subject | Extracellular matrix | pt_BR |
Subject | Macrophages | pt_BR |
Subject | Neutrophils | pt_BR |