Author | Andrade, Priscila Ribeiro | |
Author | Jardim, Márcia Rodrigues | |
Author | Silva, Ana Caroline Costa da | |
Author | Manhaes, Paula Saraiva | |
Author | Antunes, Sérgio Luiz Gomes | |
Author | Vital, Robson | |
Author | Prata, Rhana Berto da Silva | |
Author | Petito, Rafael Braga | |
Author | Pinheiro, Roberta Olmo | |
Author | Sarno, Euzenir Nunes | |
Access date | 2017-03-06T19:29:39Z | |
Available date | 2017-03-06T19:29:39Z | |
Document date | 2016 | |
Citation | ANDRADE, Priscila Ribeiro; et al. Inflammatory Cytokines Are Involved in Focal Demyelination in Leprosy Neuritis. J. Neuropathol Exp Neurol, v.75, n.3, p.272-283, Mar. 2016. | pt_BR |
ISSN | 0022-3069 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/17952 | |
Language | eng | pt_BR |
Publisher | Oxford University Press | pt_BR |
Rights | restricted access | |
Subject in Portuguese | Mycobacterium leprae | pt_BR |
Subject in Portuguese | Fator de Necrose Tumoral alfa | pt_BR |
Subject in Portuguese | Neuropatia | pt_BR |
Subject in Portuguese | Células de Schwann | pt_BR |
Subject in Portuguese | IL-23 | pt_BR |
Subject in Portuguese | Hanseníase | pt_BR |
Title | Inflammatory Cytokines Are Involved in Focal Demyelination in Leprosy Neuritis | pt_BR |
Type | Article | |
DOI | 10.1093/jnen/nlv027 | |
Abstract | Mycobacterium leprae (ML) infection causes nerve damage that often leads to permanent loss of cutaneous sensitivity and limb deformities, but understanding of the pathogenesis of leprous neuropathy that would lead to more effective treatments is incomplete. We studied reactional leprosy patients with (n = 9) and without (n = 8) acute neuritis. Nerve conduction studies over the course of the reactional episode showed the findings of demyelination in all patients with neuritis. Evaluation of patient sera revealed no correlation of the presence of antibodies against gangliosides and the clinical demyelination. In nerve biopsies of 3 patients with neuritis, we identified tumor necrosis factor (TNF), TNF receptors, and TNF-converting enzyme in Schwann cells (SCs) using immunofluorescence. To elucidate immunopathogenetic mechanisms, we performed experiments using a human SC line. ML induced transmembrane TNF and TNF receptor 1 expression in the SCs; TNF also induced interleukin (IL)- 6 and IL-8 production by the SCs; and ML induced IL-23 secretion, indicating involvement of this previously unrecognized factor in leprosy nerve damage. These data suggest that ML may contribute to TNF-mediated inflammation and focal demyelination by rendering SCs more sensitive to TNF within the nerves of patients with leprous neuropathy. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Hospital Universitário Pedro Ernesto. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Hospital Universitário Pedro Ernesto. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Demyelination | pt_BR |
Subject | IL-23 | pt_BR |
Subject | Leprosy | pt_BR |
Subject | Mycobacterium leprae | pt_BR |
Subject | Neuropathy | pt_BR |
Subject | Schwann cells | pt_BR |
Subject | Tumor necrosis factor | pt_BR |
e-ISSN | 1554-6578 | |
Embargo date | 2030-01-01 | |