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ASSOCIATION BETWEEN DIABETES AND TUBERCULOSIS: CASE-CONTROL STUDY
Tuberculose
Epidemiologia.
Comorbidade
Estudos de caso-controle
Author
Affilliation
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Departamento de Saúde Coletiva. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Estadual de Feira de Santana. Departamento de Saúde. Feira de Santana, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Estadual de Feira de Santana. Departamento de Saúde. Feira de Santana, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract
To test the association between diabetes and tuberculosis. METHODS: It is a case-control study, matched by age and sex. We included 323 new cases of
tuberculosis with positive results for bacilloscopy. The controls were 323 respiratory symptomatic
patients with negative bacilloscopy, from the same health services, such as: ambulatory cases from
three referral hospitals and six basic health units responsible for the notifications of new cases of
tuberculosis in Salvador, Bahia. Data collection occurred between 2008 and 2010. The instruments
used were structured interview, including clinical data, capillary blood glucose (during fasting
or postprandial), and the CAGE questionnaire for screening of abusive consumption of alcohol.
Descriptive, exploratory, and multivariate analysis was performed using conditional logistic
regression.
RESULTS: The average age of the cases was 38.5 (SD = 14.2) years and of the controls, 38.5
(SD = 14.3) years. Among cases and controls, most subjects (61%) were male. In univariate analysis
we found association between the occurrence of diabetes and tuberculosis (OR = 2.37; 95%CI
1.04–5.42), which remained statistically significant after adjustment for potential confounders
(OR = 3.12; 95%CI 1.12–7.94).
CONCLUSIONS: The association between diabetes and tuberculosis can hinder the control
of tuberculosis, contributing to the maintainance of the disease burden. The situation demands
increasing early detection of diabetes among people with tuberculosis, in an attempt to improve
disease control strategies
Keywords in Portuguese
Diabetes MellitusTuberculose
Epidemiologia.
Comorbidade
Estudos de caso-controle
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