Author | Rios, Fernanda Ferreira | |
Author | Freitas, Luiz Antonio Rodrigues de | |
Author | Codes, Liana | |
Author | Santos Junior, Genario Oliveira | |
Author | Schinoni, Maria Isabel | |
Author | Paraná, Raymundo | |
Access date | 2017-03-03T18:07:33Z | |
Available date | 2017-03-03T18:07:33Z | |
Document date | 2016 | |
Citation | RIOS, F. F. et al. Hepatoportal sclerosis related to the use of herbals and nutritional supplements. Causality or coincidence? Annals of Hepatology, v. 15, n. 6, p. 932-938, 2016. | pt_BR |
ISSN | 1665-2681 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/17926 | |
Language | eng | pt_BR |
Publisher | Desconhecida | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Fibrose portal não cirrótica | pt_BR |
Subject in Portuguese | Esclerose hepatoportal | pt_BR |
Subject in Portuguese | Venopatia portal obliterante | pt_BR |
Subject in Portuguese | Fígado. | pt_BR |
Subject in Portuguese | Hepatotoxicidade Herbalife | pt_BR |
Title | Hepatoportal sclerosis related to the use of herbals and nutritional supplements. Causality or coincidence? | pt_BR |
Type | Article | pt_BR |
DOI | 10.5604/16652681.1222113 | |
Abstract | Introduction and aim. Non-cirrhotic idiopathic portal hypertension (NCIPH), also known as hepatoportal sclerosis (HPS) is a disease of uncertain etiology. However, various pathophysiological mechanisms has been postulated, including chronic or recurrent infections and exposure to drugs or toxins. In this context, it appears to be of multifactorial etiology or resulting from a portal vascular endothelium aggression. It is important to consider whether the use of dietary supplements and herbs can trigger or contribute to the occurance of HPS. We report a possible association of HPS with the consumption of herbals and / or dietary supplements.Material and methods. We describe two cases of HPS in patients without known etiology causes associated with
this disease. Results. Both patients were females who were diagnosed with HPS following the consumption of Herbalife® products
and putative anorexigenic agents in the herbal infusions. Image-based analysis and the assessment of the histopathological alterations
found in the livers confirmed the diagnosis. The histopatological analysis of liver samples from both patients showed portal
tracts enlarged by fibrosis with disappearance or reduction in the diameter of the portal vein branches. In many portal tracts, portal veins
branches were replaced by aberrant thin-walled fendiforme vessels. The bile ducts and branches of the hepatic artery show normal aspects.
Conclusion. After the exclusion of other etiologic factors and a comprehensive analysis of clinical history, consumption of
Herbalife® products and anorexigenic agents was pointed-out as a puttative predisposing factor for the development of the disease. | pt_BR |
Affilliation | Federal University of Bahia. School of Medical Sciences. Salvador, BA, Brazil | pt_BR |
Affilliation | Federal University of Bahia. School of Medical Sciences. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. LPBI. Department of Pathology. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Prof. Edgard Santos University Hospital. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Prof. Edgard Santos University Hospital. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. School of Medical Sciences. Salvador, BA, Brazil / Federal University of Bahia. Institute of Science and Health. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. School of Medical Sciences. Salvador, BA, Brazil / Federal University of Bahia. Prof. Edgard Santos University Hospital. Salvador, BA, Brasil | pt_BR |
Subject | Non-cirrhotic portal fibrosis | pt_BR |
Subject | Hepatoportal sclerosis | pt_BR |
Subject | Obliterative portal venopathy | pt_BR |
Subject | Liver | pt_BR |
Subject | Herbalife hepatotoxicity | pt_BR |