Author | Menezes, Paula dos Passos | |
Author | Santos, Polliana Barbosa Pereira dos | |
Author | Dória, Grace Anne Azevedo | |
Author | Sousa, Bruna Maria Hipólito de | |
Author | Serafini, Mairim Russo | |
Author | Nunes, Paula Santos | |
Author | Quintans Júnior, Lucindo José | |
Author | Matos, Iara Lisboa de | |
Author | Alves, Péricles Barreto | |
Author | Bezerra, Daniel Pereira | |
Author | Mendonça Júnior, Francisco Jaime Bezerra | |
Author | Silva, Gabriel Francisco da | |
Author | Aquino, Thiago Mendonça de | |
Author | Bento, Edson de Souza | |
Author | Scotti, Marcus Tullius | |
Author | Scotti, Luciana | |
Author | Araujo, Adriano Antunes de Souza | |
Access date | 2017-02-16T11:49:12Z | |
Available date | 2017-02-16T11:49:12Z | |
Document date | 2017 | |
Citation | MENEZES, Paula dos Passos et al. Molecular modeling and physicochemical properties of supramolecular complexes of limonene with α- and β-Cyclodextrins. AAPS PharmSciTech, v. 18, n. 1, p. 49-57, 2017. | pt_BR |
ISSN | 1530-9932 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/17831 | |
Sponsorship | CAPES, CNPq, FINEP, FAPITEC/SE | pt_BR |
Language | eng | pt_BR |
Publisher | AAPS | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Ciclodextrina | pt_BR |
Subject in Portuguese | Complexo de inclusão | pt_BR |
Subject in Portuguese | Limoneno | pt_BR |
Subject in Portuguese | Monoterpeno | pt_BR |
Title | Molecular modeling and physicochemical properties of supramolecular complexes of limonene with α- and β-Cyclodextrins | pt_BR |
Type | Article | pt_BR |
DOI | 10.1208/s12249-016-0516-0 | |
Abstract | This study evaluated three different methods for the formation of an inclusion complex between alpha- and beta-cyclodextrin (α- and β-CD) and limonene (LIM) with the goal of improving the physicochemical properties of limonene. The study samples were prepared through physical mixing (PM), paste complexation (PC), and slurry complexation (SC) methods in the molar ratio of 1:1 (cyclodextrin:limonene). The complexes prepared were evaluated with thermogravimetry/derivate thermogravimetry, infrared spectroscopy, X-ray diffraction, complexation efficiency through gas chromatography/mass spectrometry analyses, molecular modeling, and nuclear magnetic resonance. The results showed that the physical mixing procedure did not produce complexation, but the paste and slurry methods produced inclusion complexes, which demonstrated interactions outside of the cavity of the CDs. However, the paste obtained with β-cyclodextrin did not demonstrate complexation in the gas chromatographic technique because, after extraction, most of the limonene was either surface-adsorbed by β-cyclodextrin or volatilized during the procedure. We conclude that paste complexation and slurry complexation are effective and economic methods to improve the physicochemical character of limonene and could have important applications in pharmacological activities in terms of an increase in solubility. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Farmácia. São Cristóvão, SE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Farmácia. São Cristóvão, SE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Farmácia. São Cristóvão, SE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Farmácia. São Cristóvão, SE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Farmácia. São Cristóvão, SE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Farmácia. São Cristóvão, SE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Fisiologia. São Cristóvão, SE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Química. São Cristóvão, SE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Química. São Cristóvão, SE, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Estadual da Paraíba. Laboratório de Síntese e Vectorização de Moléculas. Campina Grande, PB, Brasil. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Engenharia Química. São Cristóvão, SE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Laboratório de Ressonância Magnética Nuclear. Maceió, AL, Brasil. | pt_BR |
Affilliation | Universidade Federal da Paraíba. João Pessoa, PB, Brasil. | pt_BR |
Affilliation | Universidade Federal da Paraíba. João Pessoa, PB, Brasil. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Farmácia. São Cristóvão, SE, Brasil. | pt_BR |
Subject | Cyclodextrin | pt_BR |
Subject | Inclusion complex | pt_BR |
Subject | Limonene | pt_BR |
Subject | Monoterpene | pt_BR |
DeCS | Limoneno Hidroxilases | pt_BR |