Author | Galvão, Stanley de S. L. | |
Author | Monteiro, Andrea de S. | |
Author | Siqueira Filho, Ezequias Pessoa de | |
Author | Bomfim, Maria Rosa Quaresma | |
Author | Souza, Marcus Vinícius Dias | |
Author | Ferreira, Gabriella F. | |
Author | Denadai, Angelo Márcio Leite | |
Author | Santos, Áquila R. C. | |
Author | Santos, Vera Lúcia dos | |
Author | Fagundes, Elaine M. de Souza | |
Author | Fernandes, Elizabeth S. | |
Author | Monteiro Neto, Valério | |
Access date | 2017-02-14T18:18:07Z | |
Available date | 2017-02-14T18:18:07Z | |
Document date | 2016 | |
Citation | GALVÃO, Stanley de S. L. et al. Annona glabra Flavonoids Act As Antimicrobials by Binding to Pseudomonas aeruginosa Cell Walls. Front Microbiol, v. 7, art. 2053, 2016. | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/17815 | |
Language | eng | pt_BR |
Publisher | Frontiers Research Foundation | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Annona glabra | pt_BR |
Subject in Portuguese | Pseudomonas aeruginosa | pt_BR |
Title | Annona glabra Flavonoids Act As Antimicrobials by Binding to Pseudomonas aeruginosa Cell Walls | pt_BR |
Type | Article | pt_BR |
DOI | 10.3389/fmicb.2016.02053 | |
Abstract | Pseudomonas aeruginosa is an important pathogen in opportunistic infections in humans. The increased incidence of antimicrobial-resistant P. aeruginosa isolates has highlighted the need for novel and more potent therapies against this microorganism. Annona glabra is known for presenting different compounds with diverse biological activities, such as anti-tumor and immunomodulatory activities. Although other species of the family display antimicrobial actions, this has not yet been reported for A. glabra. Here, we investigated the antimicrobial activity of the ethyl acetate fraction (EAF) obtained from the leaf hydroalcoholic extract of A. glabra. EAF was bactericidal against different strains of P. aeruginosa. EAF also presented with a time- and concentration-dependent effect on P. aeruginosa viability. Testing of different EAF sub-fractions showed that the sub-fraction 32-33 (SF32-33) was the most effective against P. aeruginosa. Analysis of the chemical constituents of SF32-33 demonstrated a high content of flavonoids. Incubation of this active sub-fraction with P. aeruginosa ATCC 27983 triggered an endothermic reaction, which was accompanied by an increased electric charge, suggesting a high binding of SF32-33 compounds to bacterial cell walls. Collectively, our results suggest that A. glabra-derived compounds, especially flavonoids, may be useful for treating infections caused by P. aeruginosa. | pt_BR |
Affilliation | Universidade CEUMA. Centro de Ciências da Saúde. São Luís, MA, Brazil | pt_BR |
Affilliation | Universidade CEUMA. Centro de Ciências da Saúde. São Luís, MA, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade CEUMA. Centro de Ciências da Saúde. São Luís, MA, Brazil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Departamento de Microbiologia. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Juiz de Fora. Departamento de Farmácia. Governador Valadares, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Juiz de Fora. Departamento de Farmácia. Governador Valadares, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Juiz de Fora. Departamento de Farmácia. Governador Valadares, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Departamento de Microbiologia. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Departamento de Fisiologia e Biofisica. Belo Horizonte, MG,Brazil | pt_BR |
Affilliation | Universidade CEUMA. Centro de Ciências da Saúde. São Luís, MA, Brazil | pt_BR |
Affilliation | Universidade CEUMA. Centro de Ciências da Saúde. São Luís, MA, Brazil/Universidade Federal do Maranhão. Departamento de Patologia. São Luís, MG, Brazil | pt_BR |
Subject | Annona glabra | pt_BR |
Subject | Pseudomonas aeruginosa | pt_BR |
Subject | antimicrobial activity | pt_BR |
Subject | flavonoids | pt_BR |
e-ISSN | 1664-302X | |
Embargo date | 2021-01-01 | |