Author | Schmidt, Thomas Josef | |
Author | Khalid, Sami Ahmed | |
Author | Romanha, Alvaro Jose | |
Author | Alves, Tania Maria Almeida | |
Author | Biavatti, Maique Weber | |
Author | Brun, Reto | |
Author | Costa, Fernando Batista da | |
Author | Castro, Solange Lisboa de | |
Author | Ferreira, Vitor Francisco | |
Author | Lacerda, Marcus Vinícius Guimarães de | |
Author | Lago, Joao Henrique Ghilardi | |
Author | Leon, Leonor Laura Pinto | |
Author | Lopes, Norberto Peporine | |
Author | Amorim, Rodrigo César das Neves | |
Author | Niehues, Michael | |
Author | Ogungbe, Ifedayo Victor | |
Author | Pohlit, Adrian Martin | |
Author | Scotti, Marcus Tullius | |
Author | Setzer, William N. | |
Author | Soeiro, Maria de Nazaré Correia | |
Author | Steindel, Mario | |
Author | Cardoso, André Gustavo Tempone | |
Access date | 2017-02-08T17:09:52Z | |
Available date | 2017-02-08T17:09:52Z | |
Document date | 2012 | |
Citation | SCHMIDT, Thomas Josef et al. The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - Part I. Current Medicinal Chemistry, v. 19, n. 14, p. 2128-2175, 2012. | pt_BR |
ISSN | 0929-8673 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/17750 | |
Language | eng | pt_BR |
Publisher | Ingenta Connect Bentham Science Publishing | pt_BR |
Rights | restricted access | pt_BR |
Title | The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - Part I | pt_BR |
Type | Article | pt_BR |
DOI | 10.2174/092986712800229023 | |
Abstract | Infections with protozoan parasites are a major cause of disease and mortality in many tropical countries of the world. Diseases caused by species of the genera Trypanosoma (Human African Trypanosomiasis and Chagas Disease) and Leishmania (various forms of Leishmaniasis) are among the seventeen “Neglected Tropical Diseases” (NTDs) defined as such by WHO due to the neglect of financial investment into research and development of new drugs by a large part of pharmaceutical industry and neglect of public awareness in high income countries. Another major tropical protozoan disease is malaria (caused by various Plasmodium species), which -although not mentioned currently by the WHO as a neglected disease- still represents a major problem, especially to people living under poor circumstances in tropical countries. Malaria causes by far the highest number of deaths of all protozoan infections and is often (as in this review) included in the NTDs. The mentioned diseases threaten many millions of lives world-wide and they are mostly associated with poor socioeconomic and hygienic environment. Existing therapies suffer from various shortcomings, namely, a high degree of toxicity and unwanted effects, lack of availability and/or problematic application under the life conditions of affected populations. Development of new, safe and affordable drugs is therefore an urgent need. Nature has provided an innumerable number of drugs for the treatment of many serious diseases. Among the natural sources for new bioactive chemicals, plants are still predominant. Their secondary metabolism yields an immeasurable wealth of chemical structures which has been and will continue to be a source of new drugs, directly in their native form and after optimization by synthetic medicinal chemistry. The current review, published in two parts, attempts to give an overview on the potential of such plant-derived natural products as antiprotozoal leads and/or drugs in the fight against NTDs. | pt_BR |
Affilliation | University of Münster. Institute of Pharmaceutical Biology and Phytochemistry. Münster, Germany. | pt_BR |
Affilliation | University of Science & Technology. Faculty of Pharmacy. Omdurman, Sudan. | pt_BR |
Affilliation | Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Departamento de Microbiologia, Immunologia e Parasitologia. Florianópolis, SC, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Santa Catarina. Departamento de Farmácia. Florianópolis, SC, Brasil. | pt_BR |
Affilliation | University of Basel. Swiss Tropical and Public Health Institute. Basel, Switzerland. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Ribeirão Preto, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Departamento de Química Orgânica. Instituto de Química. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Fundação de Medicina Tropical Heitor Vieira Dourado. Manaus, AM, Brasil. | pt_BR |
Affilliation | Universidade Federal de São Paulo. Instituto de Ciências Ambientais, Químicas e Farmacêuticas. Diadema, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Ribeirão Preto, SP, Brasil. | pt_BR |
Affilliation | Instituto Nacional de Pesquisa da Amazônia.Manaus, AM, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Ribeirão Preto, SP, Brasil. | pt_BR |
Affilliation | University of Alabama in Huntsville. Department of Chemistry. Huntsville, Alabama, EUA. | pt_BR |
Affilliation | Instituto Nacional de Pesquisa da Amazônia. Manaus, AM, Brasil. | pt_BR |
Affilliation | Universidade Federal da Paraíba. Centro de Ciências Aplicadas e Educação. Departamento do Engenharia e Meio Ambiente. João Pessoa, PB, Brasil. | pt_BR |
Affilliation | University of Alabama in Huntsville. Department of Chemistry. Huntsville, Alabama, EUA. | pt_BR |
Affilliation | Fundacão Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Departamento de Microbiologia, Imunologia e Parasitologia. Florianópolis, SC, Brasil. | pt_BR |
Affilliation | Instituto Adolfo Lutz. Departamento de Parasitologia. São Paulo, SP, Brasil. | pt_BR |
Subject | Neglected tropical diseases | pt_BR |
Subject | Trypanosoma | pt_BR |
Subject | Leishmania | pt_BR |
Subject | Plasmodium | pt_BR |
Subject | Natural product | pt_BR |
Subject | Monoterpene | pt_BR |
Subject | Sesquiterpene | pt_BR |
Subject | Diterpene | pt_BR |
Subject | Triterpene | pt_BR |
Embargo date | 2039-01-01 | |