Author | Lima, Clara Mônica | |
Author | Santos, Silvane Maria Braga | |
Author | Dourado, Adriana | |
Author | Carvalho, Natália Barbosa | |
Author | Bittencourt, Valéria | |
Author | Lessa, Marcus Miranda | |
Author | Siqueira, Isadora Cristina de | |
Author | Carvalho Filho, Edgar Marcelino | |
Access date | 2017-02-08T16:51:04Z | |
Available date | 2017-02-08T16:51:04Z | |
Document date | 2016 | |
Citation | LIMA, C. M. et al. Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection. Journal of Immunology Research, article ID 8402059, 2016. | pt_BR |
ISSN | 2314-8861 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/17748 | |
Language | eng | pt_BR |
Publisher | Hindawi Publishing Corporation | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Infecções por HTLV-I | pt_BR |
Subject in Portuguese | Vírus linfotrópico T humano 1 | pt_BR |
Subject in Portuguese | Regulação da expressão genética | pt_BR |
Subject in Portuguese | Humanos | pt_BR |
Subject in Portuguese | Interleucina-10 | pt_BR |
Subject in Portuguese | Proviruses | pt_BR |
Subject in Portuguese | Síndrome de Sjogren | pt_BR |
Subject in Portuguese | Necrose Tumoral | pt_BR |
Subject in Portuguese | Carga Viral | pt_BR |
Title | Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection | pt_BR |
Type | Article | pt_BR |
DOI | 10.1155/2016/8402059 | |
Abstract | The Sjögren syndrome has been diagnosed in patients with HTLV-1 associated myelopathy and dry mouth and dry eyes are documented in HTLV-1 carriers. However the diagnosis of Sjögren syndrome in these subjects has been contested. In this cross-sectional study, we evaluated the role of immunological factors and proviral load, in sicca syndrome associated with HTLV-1 in patients without myelopathy. Subjects were recruited in the HTLV-1 Clinic, from 2009 to 2011. The proviral load and cytokine levels (IFN-γ, TNF-α, IL-5, and IL-10) were obtained from a database containing the values presented by the subjects at admission in the clinic. Of the 272 participants, 59 (21.7%) had sicca syndrome and in all of them anti-Sjögren syndrome related antigen A (SSA) and antigen B (SSB) were negatives. The production of TNF-α and IFN-γ was higher in the group with sicca syndrome (P < 0.05) than in HTLV-1 infected subjects without sicca syndrome. Our data indicates that patients with sicca syndrome associated with HTLV-1 do not have Sjögren syndrome. However the increased production of TNF-α and IFN-γ in this group of patients may contribute to the pathogenesis of sicca syndrome associated with HTLV-1. | pt_BR |
Affilliation | Federal University of Bahia School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brazil / Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil / Federal University of Bahia. Department of Otolaryngology. Salvador, BA, Brazil | pt_BR |
Affilliation | Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil / National Institute of Science and Technology of Tropical Diseases (CNPq/MCT). Salvador, BA, Brazil / State University of Feira de Santana (UEFS). Department of Biological Sciences, Feira de Santana, BA, Brazil | pt_BR |
Affilliation | Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil | pt_BR |
Affilliation | Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil | pt_BR |
Affilliation | Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil | pt_BR |
Affilliation | Federal University of Bahia School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brazil / Federal University of Bahia. Department of Otolaryngology. Salvador, BA, Brazil | pt_BR |
Affilliation | Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brazil / Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil / National Institute of Science and Technology of Tropical Diseases (CNPq/MCT). Salvador, BA, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | HTLV-I Infections | pt_BR |
Subject | T-lymphotropic virus 1 Human | pt_BR |
Subject | Gene Expression Regulation | pt_BR |
Subject | Human | pt_BR |
Subject | Interleukin-10 | pt_BR |
Subject | Proviruses | pt_BR |
Subject | Sjogren's Syndrome | pt_BR |
Subject | Tumor Necrosis | pt_BR |
Subject | Viral Load | pt_BR |