Author | Gonçalves, Rozana Oliveira | |
Author | Fraga, Lucas Rosa | |
Author | Santos, Wendell Vilas Boas | |
Author | Carvalho, Acácia Fernandes Lacerda de | |
Author | Cerqueira, Bruno Antonio Veloso | |
Author | Sarno, Manoel Alfredo Curvelo | |
Author | Toralles, Maria Betania P | |
Author | Vieira, M J | |
Author | Dutra, C G | |
Author | Schüler-Faccini, Lavínia | |
Author | Sanseverino, Maria Teresa Vieira | |
Author | Gonçalves, Marilda de Souza | |
Author | Vianna, Fernanda Sales Luiz | |
Author | Costa, Olivia Lucia Nunes | |
Access date | 2016-12-05T18:45:10Z | |
Available date | 2016-12-05T18:45:10Z | |
Document date | 2016 | |
Citation | GONÇALVES, R. O. et. al. Association between the thrombophilic polymorphisms MTHFR C677T, Factor V Leiden, and prothrombin G20210A and recurrent miscarriage in Brazilian women. Genetics and Molecular Research, v. 15, n. 3, p. gmr.15038156, 2016. | pt_BR |
ISSN | 1676-5680 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/16427 | |
Sponsorship | CNPq contract grant (#620219/2008-4) provided by the Brazilian Minister for Health (FIOCRUZ). | pt_BR |
Language | eng | pt_BR |
Publisher | Fundação Norte-Rio-Grandense de Pesquisa e Cultura | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Aborto | pt_BR |
Subject in Portuguese | Protrombina | pt_BR |
Subject in Portuguese | Polimorfismo | pt_BR |
Subject in Portuguese | Trombose | pt_BR |
Subject in Portuguese | Humanos | pt_BR |
Subject in Portuguese | Feminino | pt_BR |
Subject in Portuguese | Aconselhamento genético | pt_BR |
Title | Association between the thrombophilic polymorphisms MTHFR C677T, Factor V Leiden, and prothrombin G20210A and recurrent miscarriage in Brazilian women | pt_BR |
Type | Article | pt_BR |
DOI | 10.4238/gmr.15038156 | |
Abstract | Some cases of recurrent first trimester miscarriage have a thrombotic etiology. The aim of this study was to investigate the prevalence of the most common thrombophilic mutations - factor V (FV) Leiden G1691A (FVL), prothrombin (FII) G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T - in women with recurrent miscarriages. In this case-control study, we included 137 women with two or more consecutive first-trimester miscarriages (£12 weeks of gestation) and 100 healthy women with no history of pregnancy loss, and with at least one living child. DNA was extracted from the patient samples, and the relevant genes (FVL, FII, and MTHFR) were amplified by PCR, followed by restriction fragment length polymorphism, to assess the polymorphisms in these genes. The allelic frequencies of polymorphisms were not significantly different between the case and control groups. Polymorphisms in the MTHFR, FVL, and FII genes were not associated with recurrent miscarriage during the first trimester of pregnancy in Brazilian women (P = 0.479; P = 0.491 and P = 0.107, respectively). However, the etiologic identification of genetic factors is important for genetic counseling. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Genética e Biologia Molecular. Porto Alegre, RS, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Genética e Biologia Molecular. Porto Alegre, RS, Brasil | pt_BR |
Affilliation | Universidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Genética e Biologia Molecular. Porto Alegre, RS, Brasil / Hospital de Clínicas de Porto Alegre. Serviço de Genética Médica. Porto Alegre, RS, Brasil | pt_BR |
Affilliation | Hospital de Clínicas de Porto Alegre. Serviço de Genética Médica. Porto Alegre, RS, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Genética e Biologia Molecular. Porto Alegre, RS, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Subject | Recurrent miscarriage | pt_BR |
Subject | First trimester miscarriage | pt_BR |
Subject | Factor V Leiden | pt_BR |
Subject | Methylenetetrahydrofolate reductase C677T | pt_BR |
Subject | FII G20210A | pt_BR |