Author | Conceição, Elisabete Lopes | |
Author | Sampaio, Francisco Soares Nascimento | |
Author | Schwingel, Paulo Adriano | |
Author | Oliveira, Evelin S. | |
Author | Rocha, Michael Santos | |
Author | Vieira, Igor | |
Author | Mendes, Carlos M. C. | |
Author | Machado, Adelmir Souza | |
Author | Oliveira, Martha M. | |
Author | Barral Netto, Manoel | |
Author | Marinho, Jamocyr Moura | |
Author | Bessa, Theolis Costa Barbosa | |
Access date | 2016-12-02T16:10:58Z | |
Available date | 2016-12-02T16:10:58Z | |
Document date | 2016 | |
Citation | CONCEIÇÃO, E. L. et al. Revisiting the Heterogeneous IFN-γ Response of Bacille of Calmette-Guérin (BCG)-Revaccinated Healthy Volunteers in a Randomized Controlled Trial: Effect of the Body Mass Index and of the IFNG+874 A/T Polymorphism. PLoS ONE, v. 11, n. 7, p. e0160149, 2016. | pt_BR |
ISSN | 1932-6203 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/16418 | |
Sponsorship | Fundação de Amparo a Pesquisa do Estado da Bahia—FAPESB (002/03-PPP). ELC received a scholarship from Coordenação de Aperfeicoamento de Pessoal de Nivel Superior—CAPES. ESO and MSR received scholarships from FAPESB. | pt_BR |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Bacilo de Calmette-Guérin | pt_BR |
Subject in Portuguese | BCG | pt_BR |
Subject in Portuguese | Vacinas | pt_BR |
Subject in Portuguese | Nutrição | pt_BR |
Subject in Portuguese | Tuberculose | pt_BR |
Subject in Portuguese | Brasil | pt_BR |
Subject in Portuguese | Revacinação | pt_BR |
Subject in Portuguese | Polimorfismo | pt_BR |
Title | Revisiting the Heterogeneous IFN-γ Response of Bacille of Calmette-Guérin (BCG)-Revaccinated Healthy Volunteers in a Randomized Controlled Trial: Effect of the Body Mass Index and of the IFNG+874 A/T Polymorphism | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pone.0160149 | |
Abstract | In trials evaluating the immune responses to Bacille of Calmette-Guérin (BCG), the genetic background and the nutritional status are host-related factors that could affect the heterogeneity in these parameters. The IFNG+874 A/T (rs 62559044) polymorphism has been reported to influence the IFN-γ production by BCG-vaccinated individuals challenged in vitro with mycobacterial antigens. The body mass index (BMI) is a proxy for the nutritional status and has been associated both with the susceptibility to tuberculosis and with the IFN-γ response. We show that although the IFNG+874 A/T polymorphism was not associated with the heterogeneity of IFN-γ production in a randomized controlled trial that evaluated long-term immune responses to BCG revaccination previously conducted in Salvador, Bahia, Brazil, the effect of this polymorphism on the observed increase in IFN-γ production among revaccinated subjects was adjusted in individuals with a low BMI. | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Hospital Santa Izabel. Salvador, BA, Brasil | pt_BR |
Subject | Bacille of Calmette-Guérin | pt_BR |
Subject | BCG | pt_BR |
Subject | Vaccina | pt_BR |
Subject | Nutrition | pt_BR |
Subject | Tuberculosis | pt_BR |
Subject | Brasil | pt_BR |
Subject | Revaccination | pt_BR |
Subject | Polymorphism | pt_BR |