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AEROBIC EXERCISE REDUCES ASTHMA PHENOTYPE BY MODULATION OF THE LEUKOTRIENE PATHWAY
Asma
Leucotrienos
Inflamação das vias aéreas
Citocinas
Author
Custódio, Ricardo Wesley Alberca
Greiffo, Flávia Regina
MacKenzie, BreAnne
Oliveira Junior, Manoel Carneiro
Sousa, Adilson Santos Andrade
Graudenz, Gustavo Silveira
Santos, Angela Batista Gomes
Rodrigues, Nilsa Regina Damaceno
Faria Neto, Hugo Caire Castro
Costa, Fernanda Magalhaes Arantes
Martins, Milton de Arruda
Abbasi, Asghar
Lin, Chin Jia
Idzko, Marco
Oliveira, Ana Paula Ligeiro
Northoff, Hinnak
Vieira, Rodolfo Paula
Greiffo, Flávia Regina
MacKenzie, BreAnne
Oliveira Junior, Manoel Carneiro
Sousa, Adilson Santos Andrade
Graudenz, Gustavo Silveira
Santos, Angela Batista Gomes
Rodrigues, Nilsa Regina Damaceno
Faria Neto, Hugo Caire Castro
Costa, Fernanda Magalhaes Arantes
Martins, Milton de Arruda
Abbasi, Asghar
Lin, Chin Jia
Idzko, Marco
Oliveira, Ana Paula Ligeiro
Northoff, Hinnak
Vieira, Rodolfo Paula
Affilliation
Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.
Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.
Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.
Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.
Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.
Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.
Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.
University of São Paulo (USP). School of Medicine. Laboratory of Cellular Biology (LIM59). São Paulo, SP, Brazil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
University of São Paulo (USP). School of Medicine. Laboratory of Experimental Therapeutics (LIM 20). São Paulo, SP, Brazil.
University of São Paulo (USP). School of Medicine. Laboratory of Experimental Therapeutics (LIM 20). São Paulo, SP, Brazil.
University of California Irvine. Institute for Memory Impairments and Neurological Disorders (MIND Institute). Irvine, CA, USA.
University of São Paulo (USP). School of Medicine. Department of Pathology (LIM 05). São Paulo, SP, Brazil.
University Hospital Freiburg. Department of Pneumology. COPD and Asthma Research Group. Freiburg, Germany.
Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.
University of Tübingen. Department of Pneumology. Institute of Clinical and Experimental Transfusion Medicine (IKET). Tübingen, Germany.
Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.
Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.
Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.
Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.
Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.
Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.
Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.
University of São Paulo (USP). School of Medicine. Laboratory of Cellular Biology (LIM59). São Paulo, SP, Brazil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
University of São Paulo (USP). School of Medicine. Laboratory of Experimental Therapeutics (LIM 20). São Paulo, SP, Brazil.
University of São Paulo (USP). School of Medicine. Laboratory of Experimental Therapeutics (LIM 20). São Paulo, SP, Brazil.
University of California Irvine. Institute for Memory Impairments and Neurological Disorders (MIND Institute). Irvine, CA, USA.
University of São Paulo (USP). School of Medicine. Department of Pathology (LIM 05). São Paulo, SP, Brazil.
University Hospital Freiburg. Department of Pneumology. COPD and Asthma Research Group. Freiburg, Germany.
Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.
University of Tübingen. Department of Pneumology. Institute of Clinical and Experimental Transfusion Medicine (IKET). Tübingen, Germany.
Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.
Abstract
Leukotrienes (LTs) play a central role in asthma. Low- to moderate-intensity aerobic exercise (AE) reduces asthmatic inflammation in clinical studies and in experimental models. This study investigated whether AE attenuates LT pathway activation in an ovalbumin (OVA) model of asthma.
Keywords in Portuguese
Imunologia do exercícioAsma
Leucotrienos
Inflamação das vias aéreas
Citocinas
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