Author | Bello, Gonzalo | |
Author | Silva, Walter A. Eyer | |
Author | Fernandez, José C. Coutro | |
Author | Guimarães, Monick L. | |
Author | Fernandez, Saada L. Chequer | |
Author | Teixeira, Sylvia L. M. | |
Author | Morgado, Mariza G. | |
Access date | 2016-09-21T17:12:36Z | |
Available date | 2016-09-21T17:12:36Z | |
Document date | 2007 | |
Citation | BELLO, Gonzalo; et al. Demographic history of HIV-1 subtypes B and F in Brazil. Infection, Genetic and Evolution, v,7, p.263-270, 2007. | pt_BR |
ISSN | 1567-1348 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/15890 | |
Language | eng | pt_BR |
Publisher | ScienceDirect | pt_BR |
Rights | restricted access | |
Subject in Portuguese | Brasil | pt_BR |
Subject in Portuguese | HIV-1 | pt_BR |
Subject in Portuguese | Subtipo B | pt_BR |
Subject in Portuguese | Subtipo F | pt_BR |
Subject in Portuguese | História demográfica | pt_BR |
Title | Demographic history of HIV-1 subtypes B and F in Brazil | pt_BR |
Type | Article | |
DOI | 10.1016/j.meegid.2006.11.002 | |
Abstract | The reconstruction of the epidemic history of several HIV populations, by using methods that infer the population history from sampled gene sequence data, has revealed important subtype-specific and regional-specific differences in patterns of epidemic growth. Here, we employ Bayesian coalescent-based methods to compare the population history of the HIV-1 subtype B and F1 epidemics in Brazil from non-contemporary env and pol gene sequences. Our results suggest that after the introduction of the subtypes B and F1 into Brazilian population, around mid to late 1960s and late 1970s, respectively, these subtypes experienced an initial period of exponential growth with similar epidemic growth rates ( approximately 0.5-0.6year(-1)). Later, the spreading rate of both subtypes seems to have slowed-down since mid to late 1980s. This demographic pattern is very similar to that reported for the subtype B epidemics in high-income countries where HIV was initially transmitted through homosexual intercourse and injecting drug use, as in Brazil; suggesting that the characteristics of transmission networks may be a key determinant of the HIV epidemic growth pattern. It is important to note that most of the subtype B and F1 sequences used in this study come from the Southeast region that has been the most affected by the AIDS epidemic in Brazil, being responsible for around 63% of all AIDS cases reported since the early eighties; but may not represent the demographic trend of the HIV-1 epidemic in other Brazilian regions. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | |
Subject | Brazil | pt_BR |
Subject | HIV-1 | pt_BR |
Subject | Subtype B | pt_BR |
Subject | Subtype F | pt_BR |
Subject | Demographic history | pt_BR |
Subject | Bayesian | pt_BR |
Subject | Coalescent theory | pt_BR |
Embargo date | 2030-01-01 | |