Author | Chumbinho, Lucianne C. | |
Author | Pizzini, Caroline C. | |
Author | Oliveira, F. de Souza | |
Author | Batista, Wanderson | |
Author | Oliveira, Gabriel M. de | |
Access date | 2016-09-06T15:35:31Z | |
Available date | 2016-09-06T15:35:31Z | |
Document date | 2012 | |
Citation | CHUMBINHO, Lucianne C. et al. Cardiorenal interaction during the acute phase of experimental Trypanosoma cruzi infection: the influence of aldosterone and the AT1 receptor on mortality. Journal of Experimental and Integrative Medicine, v.2, n.3, p.199-206, 2012. | pt_BR |
ISSN | 1309-4572 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/15702 | |
Language | eng | pt_BR |
Publisher | GESDAV- Foundation for Education, Health, Social Cooperation and Solidairty of the People of the Gulhane | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Trypanosoma cruzi | pt_BR |
Subject in Portuguese | Lesão renal aguda | pt_BR |
Subject in Portuguese | Miocardite aguda | pt_BR |
Title | Cardiorenal interaction during the acute phase of experimental Trypanosoma cruzi infection: the influence of aldosterone and the AT1 receptor on mortality | pt_BR |
Type | Article | pt_BR |
Abstract | Introduction: Trypanosoma cruzi infection is a serious public health problem in Latin
America. Despite positive results from programs directed to the interruption of vectorial
transmission, there are still millions of people infected, and a large number, at the risk of
infection. Chagas disease is typically associated with cardiac complications, and chronic
symptoms include heart failure and megaesophagus development.
Objective: In this study, we aimed to evaluate the importance of the cardiorenal axis
and renin-angiotensin-aldosterone system (RAAS) activation in experimental T.cruzi
infection. We also evaluated the influence of aldosterone and the angiotensin II receptor
type 1 (AT1R) on the mortality of infected mice.
Methods: BALB/c mice infected with the Y strain of T.cruzi were treated with
spironolactone or losartan. We assessed parasitemia, mortality, and renal and cardiac
function by using non-invasive methods.
Results: Our data show that AT1R promotes an important (and necessary) inotropic
positive effect in the heart and minimizes acute kidney injury. Conversely, aldosterone
increases the release of K+
and aggravates heart failure. It also has associated effects on
the renal, cardiovascular, and cardiac electrical conduction systems. Consequently, the
aldosterone antagonist reduced the mortality rate by 50%, whereas the AT1R antagonist
increased it by 20%.
Conclusions: The RAAS connects the cardiorenal systems, and its components
differentially affect the mortality of animals experimentally infected by T.cruzi. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Biofilmes e Ensino. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Acute kidney injury | pt_BR |
Subject | Acute myocarditis | pt_BR |
Subject | RAAS | pt_BR |
Subject | Trypanosoma cruzi | pt_BR |
e-ISSN | 2146-3298 | |