Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/15070
IMMUNE COMPLEX DEPOSITION IN THE CHOROID PLEXUS OF PATIENTS WITH ACQUIRED IMMUNODEFICIENCY SYNDROME
Choroid Plexus
Antigen-Antibody Complex
Encephalitis
Humans
Affilliation
Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
University of Miami School of Medicine. Department of Pathology. Miami, Florida
Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
University of Miami School of Medicine. Department of Pathology. Miami, Florida
Abstract
plexus of approximately 75% of patients with acquired
immunodeficiency syndrome (AIDS) who had either
normal brains or human immunodeficiency virus encephalitis.
Since circulating immune complexes are common
in AIDS patients, and since local choroid plexus
pathology usually was absent, their likely origin is from
the bloodstream. Choroid plexus deposits of immune
complexes have been implicated in altering the function
of this structure or in enhancing its vulnerability to infection.
Therefore, immune complex deposition in the
choroid plexus of AIDS patients may be responsible for
some of the common alterations in the cerebrospinal
fluid and for the frequency of opportunistic infections
in this region.
Keywords
Acquired Immunodeficiency SyndromeChoroid Plexus
Antigen-Antibody Complex
Encephalitis
Humans
Share