Author | Carneiro, Ana Carolina Aguiar Vasconcelos | |
Author | Machado, Anderson Silva | |
Author | Béla, Samantha Ribeiro | |
Author | Costa, Julia Gatti Ladeia | |
Author | Andrade, Gláucia Manzan Queiroz | |
Author | Santos, Daniel Vitor Vasconcelos | |
Author | Januário, José Nélio | |
Author | Reis, Jordana Grazziela Alves Coelho dos | |
Author | Ferro, Eloisa Amália Vieira | |
Author | Carvalho, Andréa Teixeira de | |
Author | Vitor, Ricardo Wagner Almeida | |
Author | Martins Filho, Olindo Assis | |
Access date | 2016-07-13T18:53:25Z | |
Available date | 2016-07-13T18:53:25Z | |
Document date | 2016 | |
Citation | CARNEIRO, Ana Carolina Aguiar Vasconcelos et al. Cytokine Signatures Associated With Early Onset, Active Lesions and Late Cicatricial Events of Retinochoroidal Commitment in Infants With Congenital Toxoplasmosis. J Infect Dis., vol. 213, n. 12. P. 1962-70, 2016 | pt_BR |
ISSN | 0022-1899 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/14855 | |
Language | eng | pt_BR |
Publisher | Oxford University Press | pt_BR |
Rights | open access | pt_BR |
Title | Cytokine Signatures Associated With Early Onset, Active Lesions and Late Cicatricial Events of Retinochoroidal Commitment in Infants With Congenital Toxoplasmosis. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1093/infdis/jiw041 | |
Abstract | BACKGROUND: Ocular toxoplasmosis is a prominent and severe condition of high incidence in Brazil. The current study provides new insights into the immunological events that can be associated with retinochoroiditis in the setting of congenital toxoplasmosis in human infants.
METHODS: Flow cytometry of intracytoplasmic cytokines in leukocyte subsets following in vitro short-term antigenic recall in infants with congenital T. gondii infection.
RESULTS: Our data demonstrates that whereas neutrophils and monocytes from T. gondii-infected infants display a combination of proinflammatory and regulatory cytokine profiles, natural killer cells showed a predominantly proinflammatory profile upon in vitro T. gondii stimulation. The proinflammatory response of CD4(+) and CD8(+) T cells, characterized by the production of interferon γ (IFN-γ) and interleukin 17 in patients with an active retinochoroidal lesion, revealed the presence of IFN-γ and tumor necrosis factor α during early and late immunological events. This specific proinflammatory pattern is associated with early events and active retinochoroidal lesion, whereas a robust monocyte-derived interleukin 10-mediated profile is observed in children with cicatricial ocular lesions.
CONCLUSIONS: These findings support the existence of a progressive immunological environment concomitant with the initial, apical, and cicatricial phases in the process of retinochoroidal lesion formation in infants with congenital toxoplasmosis that may be relevant in the establishment of stage-specific clinical management. | pt_BR |
Affilliation | Núcleo de Ações e Pesquisa em Apoio Diagnóstico. Departamento de Parasitologia. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Núcleo de Ações e Pesquisa em Apoio Diagnóstico. Departamento de Parasitologia. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Grupo Integrado de Pesquisas em Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Núcleo de Ações e Pesquisa em Apoio Diagnóstico. Departamento de Parasitologia. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Núcleo de Ações e Pesquisa em Apoio Diagnóstico. Departamento de Pediatria. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Oftalmologia e Otorrinolaringologia. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Núcleo de Ações e Pesquisa em Apoio Diagnóstico. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Grupo Integrado de Pesquisas em Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Uberlândia. Uberlândia, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Grupo Integrado de Pesquisas em Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Núcleo de Ações e Pesquisa em Apoio Diagnóstico. Departamento de Parasitologia. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Grupo Integrado de Pesquisas em Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil. | pt_BR |
Subject | active and cicatricial lesions | pt_BR |
Subject | congenital toxoplasmosis | pt_BR |
Subject | cytokine profile | pt_BR |
Subject | infants | pt_BR |
Subject | retinochoroiditis | pt_BR |
Embargo date | 2018-01-01 | |