Author | Costa, Lívia Bandeira | |
Author | Cardoso, Marcos Veríssimo de Oliveira | |
Author | Oliveira Filho, Gevanio Bezerra de | |
Author | Gomes, Paulo André Teixeira de Moraes | |
Author | Espíndola, José Wanderlan Pontes | |
Author | Silva, Thays Gabrielle de Jesus | |
Author | Torres, Pedro Henrique Monteiro | |
Author | Silva Junior, Floriano Paes | |
Author | Martin, Julio | |
Author | Figueiredo, Regina Célia Bressan Queiroz de | |
Author | Leite, Ana Cristina Lima | |
Access date | 2016-07-05T11:53:37Z | pt_BR |
Access date | 2016-07-08T12:21:56Z | |
Available date | 2016-07-05T11:53:37Z | pt_BR |
Available date | 2016-07-08T12:21:56Z | |
Document date | 2016 | pt_BR |
Citation | COSTA, Lívia Bandeira; et al. Compound profiling and 3D-QSAR studies of hydrazone derivatives with activity against intracellular Trypanosoma cruzi. Bioorganic & Medicinal Chemistry, v.24, n.8, p.1608-1618, Apr. 2016. | pt_BR |
ISSN | 0968-0896 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/14767 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | pt_BR |
Title | Compound profiling and 3D-QSAR studies of hydrazone derivatives with activity against intracellular Trypanosoma cruzi | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.bmc.2016.02.027 | pt_BR |
Abstract | Chagas disease is a tropical disease caused by the parasite Trypanosoma cruzi, which is endemic in Central and South America. Few treatments are available with effectiveness limited to the early (acute) stage of disease, significant toxicity and widespread drug resistance. In this work we report the outcome of a HTS-ready assay chemical library screen to identify novel, nontoxic, small-molecule inhibitors of T. cruzi. We have selected 50 compounds that possess hydrazone as a common group. The compounds were screened using recombinant T. cruzi (Tulahuen strain) expressing beta-galactosidase. A 3D quantitative structure–activity relationship (QSAR) analysis was performed using descriptors calculated from comparative molecular field analysis (CoMFA). Our findings show that of the fifty selected hydrazones, compounds LpQM-19, 28 and 31 displayed the highest activity against T. cruzi, leading to a selectivity index (SI) of 20-fold. The 3D-QSAR analysis indicates that a particular electrostatic arrangement, where electron-deficient atoms are aligned along the molecule main axis positively correlates with compound biological activity. These results provide new candidate molecules for the development of treatments against Chagas disease. | pt_BR |
Affilliation | Universidade Federal de Pernambuco.Centro de Ciências da Saúde. Departamento de Ciências Farmacêuticas. Recife, PE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Pernambuco.Centro de Ciências da Saúde. Departamento de Ciências Farmacêuticas. Recife, PE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Pernambuco.Centro de Ciências da Saúde. Departamento de Ciências Farmacêuticas. Recife, PE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Pernambuco.Centro de Ciências da Saúde. Departamento de Ciências Farmacêuticas. Recife, PE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Pernambuco.Centro de Ciências da Saúde. Departamento de Ciências Farmacêuticas. Recife, PE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Pernambuco.Centro de Ciências da Saúde. Departamento de Ciências Farmacêuticas. Recife, PE, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica Experimental e Computacional de Fármacos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica Experimental e Computacional de Fármacos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | GlaxoSmithKline. Tres Cantos Medicines Development Campus.Molecular Discovery Research. Tres Cantos, Spain. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Microbiologia. Recife, PE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Pernambuco.Centro de Ciências da Saúde. Departamento de Ciências Farmacêuticas. Recife, PE, Brasil. | pt_BR |
Subject | Chagas disease | pt_BR |
Subject | Hydrazones | pt_BR |
Subject | Thiosemicarbazones | pt_BR |
Subject | Thiazoles | pt_BR |
Subject | 3D-QSAR | pt_BR |
Subject | Drug design | pt_BR |
DeCS | Doença de Chagas | pt_BR |
DeCS | Hidrazonas | pt_BR |
DeCS | Tiossemicarbazonas | pt_BR |
DeCS | Tiazóis | pt_BR |
DeCS | Desenho de Drogas | pt_BR |