Author | Souza, Nicolli Bellotti de | pt_BR |
Author | Aguiar, Anna Caroline Campos | pt_BR |
Author | Oliveira, Alane Cabral de | pt_BR |
Author | Top, Siden | pt_BR |
Author | Pigeon, Pascal | pt_BR |
Author | Jaouen, Gérard | pt_BR |
Author | Goulart, Marilia Oliveira Fonseca | pt_BR |
Author | Krettli, Antoniana Ursine | pt_BR |
Access date | 2016-06-22T18:47:32Z | pt_BR |
Access date | 2016-07-07T11:36:18Z | |
Available date | 2016-06-22T18:47:32Z | pt_BR |
Available date | 2016-07-07T11:36:18Z | |
Document date | 2015 | |
Citation | SOUZA, Nicolli Bellotti de et al. Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 110, n. 8, p. 981-988, Dec. 2015. | pt_BR |
ISSN | 0074-0276 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/14584 | |
Language | por | pt_BR |
Publisher | Fundação Oswaldo Cruz | pt_BR |
Rights | open access | pt_BR |
Title | Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/0074-02760150163 | pt_BR |
Abstract | This work reports the in vitro activity against Plasmodium falciparum blood forms (W2 clone, chloroquine-resistant) of tamoxifen-based compounds and their ferrocenyl (ferrocifens) and ruthenocenyl (ruthenocifens) derivatives, as well as their cytotoxicity against HepG2 human hepatoma cells. Surprisingly with these series, results indicate that the biological activity of ruthenocifens is better than that of ferrocifens and other tamoxifen-like compounds. The synthesis of a new metal-based compound is also described. It was shown, for the first time, that ruthenocifens are good antiplasmodial prototypes. Further studies will be conducted aiming at a better understanding of their mechanism of action and at obtaining new compounds with better therapeutic profile. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil / Universidade Federal de Alagoas. Faculdade de Nutrição. Maceió, AL, Brasil. | pt_BR |
Affilliation | Sorbonne Universités. Université Pierre-et-Marie-Curie. Unités Mixtes de Recherche. Paris, France. | pt_BR |
Affilliation | Sorbonne Universités. Université Pierre-et-Marie-Curie. Unités Mixtes de Recherche. Paris, France / Ecole Nationale Supérieure de Chimie de Paris. Paris, France. | pt_BR |
Affilliation | Sorbonne Universités. Université Pierre-et-Marie-Curie. Unités Mixtes de Recherche. Paris, France / Ecole Nationale Supérieure de Chimie de Paris. Paris, France. | pt_BR |
Affilliation | Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
Subject | Plasmodium falciparum | pt_BR |
Subject | Metallodrug activity | pt_BR |
Subject | Ruthenocifens | pt_BR |
Subject | Ferrocifens | pt_BR |