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https://www.arca.fiocruz.br/handle/icict/14105
FOLLOW-UP STUDY OF UNKNOWINGLY PREGNANT WOMEN VACCINATED AGAINST RUBELLA IN BRAZIL, 2001–2002
Author
Soares, Rosa Castalia
Siqueira, Marilda Agudo Mendonça Teixeira de
Toscano, Cristiana Maria
Maia, Maria de Lourdes S.
Flannery, Brendan
Sato, Helena K.
Will, Rosane M.
Rodrigues, Regina C. M.
Oliveira, Imaculada C.
Barbosa, Tânia Cristina
Sá, G. R. S.
Rego, Marta Ferreira
Curti, Sueli P.
Lemos, Xênia R.
Morhdieck, Renate
Stürmer, Denise
Oliveira, Maria José C.
Silva Jr., Jarbas Barbosa da
Castillo-Solórzano, Carlos
Camacho, Luiz A. B.
Luna, Expedito
Siqueira, Marilda Agudo Mendonça Teixeira de
Toscano, Cristiana Maria
Maia, Maria de Lourdes S.
Flannery, Brendan
Sato, Helena K.
Will, Rosane M.
Rodrigues, Regina C. M.
Oliveira, Imaculada C.
Barbosa, Tânia Cristina
Sá, G. R. S.
Rego, Marta Ferreira
Curti, Sueli P.
Lemos, Xênia R.
Morhdieck, Renate
Stürmer, Denise
Oliveira, Maria José C.
Silva Jr., Jarbas Barbosa da
Castillo-Solórzano, Carlos
Camacho, Luiz A. B.
Luna, Expedito
Affilliation
National Immunization Program
Secretariat of Public Health Surveillance
Fundação Nacional de Saúde (FUNASA)
Pan American Health Organization, Brasilia
Measles and Respiratory Viruses Laboratory
National School of Public Health, Oswaldo Cruz Foundation/FIOCRUZ
Department of Rio de Janeiro State Health, Rio de Janeiro
Epidemiologic Surveillance Unit, Adolfo Lutz Institute, São Paulo State Health Department, São Paulo
Bahia State Health Department and Public Health Laboratory, Salvador
Minas Gerais State Health Department and Central Public Health Laboratory, Belo Horizonte
Department of Goiás State Health, Goiania
Rio Grande do Sul State Health Department and Central Public Health Laboratory, Porto Alegre
Pernambuco State Health Department and Central Public Health Laboratory, Recife, Brazil
Pan American Health Organization, Washington, D.C.
Instituto Tecnológico em Imunobiológicos, Fundação Oswaldo Cruz
Secretariat of Public Health Surveillance
Fundação Nacional de Saúde (FUNASA)
Pan American Health Organization, Brasilia
Measles and Respiratory Viruses Laboratory
National School of Public Health, Oswaldo Cruz Foundation/FIOCRUZ
Department of Rio de Janeiro State Health, Rio de Janeiro
Epidemiologic Surveillance Unit, Adolfo Lutz Institute, São Paulo State Health Department, São Paulo
Bahia State Health Department and Public Health Laboratory, Salvador
Minas Gerais State Health Department and Central Public Health Laboratory, Belo Horizonte
Department of Goiás State Health, Goiania
Rio Grande do Sul State Health Department and Central Public Health Laboratory, Porto Alegre
Pernambuco State Health Department and Central Public Health Laboratory, Recife, Brazil
Pan American Health Organization, Washington, D.C.
Instituto Tecnológico em Imunobiológicos, Fundação Oswaldo Cruz
Abstract
Brazil conducted mass immunization of women of childbearing age in 2001 and 2002. Surveillance was initiated for vaccination of women during pregnancy to monitor the effects of rubella vaccination on fetal outcomes.
Methods. Women vaccinated while pregnant or prior to conception were reported to the surveillance system.
Susceptibility to rubella infection was determined by anti-rubella immunoglobulin (Ig) M and IgG immunoassays. Susceptible women were observed through delivery. Live-born infants were tested for anti-rubella IgM antibody; IgM-seropositive newborns were tested for viral shedding and observed for 12 months for signs of congenital rubella syndrome. Incidence of congenital rubella infection was calculated using data from 7 states.
Results. A total of 22 708 cases of rubella vaccination during pregnancy or prior to conception were reported
nationwide, 20 536 (90%) of which were from 7 of 27 states in Brazil. Of these, 2332 women were susceptible to
rubella infection at vaccination. Sixty-seven (4.1%) of 1647 newborns had rubella IgM antibody (incidence rate, 4.1
congenital infections per 100 susceptible women vaccinated during pregnancy [95% confidence interval, 3.2–5.1]).
None of the infants infected with rubella vaccine virus was born with congenital rubella syndrome.
Conclusions. As rubella elimination goals are adopted worldwide, evidence of rubella vaccine safety aids in planning and implementation of mass adult immunization.
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