Author | Santos, Claire da Silva | |
Author | Attarha, Sanaz | |
Author | Saini, Ravi Kanth | |
Author | Boaventura, Viviane | |
Author | Costa, Jackson Mauricio Lopes | |
Author | Cunha, Antonio Ricardo Khouri | |
Author | Barral Netto, Manoel | |
Author | Brodskyn, Claudia Ida | |
Author | Souchelnytskyi, Serhiy | |
Access date | 2016-05-03T18:40:03Z | |
Available date | 2016-05-03T18:40:03Z | |
Document date | 2015 | |
Citation | SANTOS, C. S. et al. Proteome profiling of human cutaneous leishmaniasis lesion. Journal of Investigative Dermatology, v. 135, n. 2, p. 400-410, 2015. | pt_BR |
ISSN | 1523-1747 | |
URI | https://www.arca.fiocruz.br/handle/icict/14081 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Title | Proteome profiling of human cutaneous leishmaniasis lesion. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1038/jid.2014.396 | |
Abstract | In this study, we used proteomics and biological network analysis to evaluate the potential biological processes and components present in the identified proteins of biopsies from cutaneous leishmaniasis (CL) patients infected by Leishmania braziliensis in comparison with normal skin. We identified 59 proteins differently expressed in samples from infected and normal skin. Biological network analysis employing identified proteins showed the presence of networks that may be involved in the cell death mediated by cytotoxic T lymphocytes. After immunohistochemical analyses, the expression of caspase-9, caspase-3, and granzyme B was validated in the tissue and positively correlated with the lesion size in CL patients. In conclusion, this work identified differentially expressed proteins in the inflammatory site of CL, revealed enhanced expression of caspase-9, and highlighted mechanisms associated with the progression of tissue damage observed in lesions. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Ba, Brasil | pt_BR |
Affilliation | Karolinska Institutet. Department of Oncology-Pathology. Stockholm, Sweden | pt_BR |
Affilliation | Karolinska Institutet. Department of Oncology-Pathology. Stockholm, Sweden | pt_BR |
Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Ba, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Ba, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Ba, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. São Paulo, SP, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Ba, Brasil / Instituto de Investigação em Imunologia. São Paulo, SP, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil | pt_BR |
Affilliation | Karolinska Institutet. Department of Oncology-Pathology. Stockholm, Sweden | pt_BR |
DeCS | Leishmaniose Cutânea/metabolismo | pt_BR |
DeCS | Proteoma | pt_BR |
DeCS | Caspase 3/análise | pt_BR |
DeCS | Caspase 9/análise | pt_BR |
DeCS | Granzimas/análise | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Imuno-Histoquímica | pt_BR |
DeCS | Leishmaniose Cutânea/patologia | pt_BR |
DeCS | Pele/patologia | pt_BR |