Author | Mendonça, Vitor Rosa Ramos de | |
Author | Andrade, Bruno de Bezerril | |
Author | Souza, Ligia C L | |
Author | Magalhães, Belisa Maria Lopes | |
Author | Mourão, Maria Paula Gomes | |
Author | Lacerda, Marcus Vinícius Guimarães de | |
Author | Barral Netto, Manoel | |
Access date | 2016-04-26T17:32:23Z | |
Available date | 2016-04-26T17:32:23Z | |
Document date | 2015 | |
Citation | MENDONÇA, V. R. R. et al. Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection. Malaria Journal, v. 14, p. 315, 2015. | pt_BR |
ISSN | 1475-2875 | |
URI | https://www.arca.fiocruz.br/handle/icict/13976 | |
Language | eng | pt_BR |
Publisher | BioMed Central | pt_BR |
Rights | open access | pt_BR |
Title | Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection | pt_BR |
Type | Article | pt_BR |
DOI | 10.1186/s12936-015-0835-8 | |
Abstract | Background: Concurrent malaria and dengue infection is frequently diagnosed in endemic countries, but its
immunopathology remains largely unknown. In the present study, a large panel of cytokines/chemokines and clinical
laboratory markers were measured in patients with Plasmodium vivax and dengue co-infection as well as in individuals
with malaria or dengue mono-infections in order to identify biosignatures of each clinical condition.
Methods: Individuals from the Brazilian Amazon were recruited between 2009 and 2013 and classified in three
groups: vivax malaria (n = 52), dengue (n = 30) and vivax malaria and dengue co-infection (n = 30). P. vivax malaria
was diagnosed by thick blood smear and confirmed by PCR; dengue cases were detected by IgM ELISA or NS1 protein.
The plasma levels of cytokines and chemokines were determined by multiplex assay.
Results: Individuals with malaria and dengue co-infection displayed lower levels of platelets and haemoglobin than
those with malaria or dengue mono-infections (p = 0.0047 and p = 0.0001, respectively). The group of individuals coinfected
exhibited the highest median concentrations of IFN-γ, IL-6, CCL4 than the mono-infected groups. Network
analyses of plasma cytokines/chemokines revealed that malaria and dengue co-infection exhibits a distinct immune
profile with critical roles for TNF, IL-6 and IFN-γ. Further, parasitaemia levels displayed positive significant interactions
with IL-6, CCL4 and IL-10 in the group of patients co-infected with malaria and dengue. No differences were observed
in distribution of dengue virus serotypes and Plasmodium parasitaemia levels between the groups.
Conclusions: The findings described here identify unique patterns of circulating immunological markers in cases of
malaria and dengue co-infection and provide insights on the immunopathology of this co-morbid condition. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiogia e Imunoregulação. LIMI. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiogia e Imunoregulação. LIMI. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiogia e Imunoregulação. LIMI. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, Brasil | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, Brasil | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiogia e Imunoregulação. LIMI. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia. Instituto de Investigação em Imunologia. São Paulo, SP, Brasil | pt_BR |
Subject | Immune response | pt_BR |
Subject | Co-infection | pt_BR |
Subject | Dengue | pt_BR |
Subject | Plasmodium vivax | pt_BR |
Subject | Malaria | pt_BR |