Author | Moreira, Luciano Andrade | |
Author | Iturbe-Ormaetxe, Iñaki | |
Author | Jeffery, Jason A. | |
Author | Lu, Guangjin | |
Author | Pyke, Alyssa T. | |
Author | Hedges, Lauren M. | |
Author | Rocha, Bruno Coelho | |
Author | Hall-Mendelin, Sonja | |
Author | Day, Andrew | |
Author | Riegler, Markus | |
Author | Hugo, Leon E. | |
Author | Johnson, Karyn N. | |
Author | Kay, Brian H. | |
Author | McGraw, Elizabeth A. | |
Author | Hurk, Andrew F. van den | |
Author | Ryan, Peter A. | |
Author | O'Neill, Scott L. | |
Access date | 2016-04-11T14:11:58Z | |
Available date | 2016-04-11T14:11:58Z | |
Document date | 2009 | |
Citation | MOREIRA, Luciano Andrade et al. A Wolbachia Symbiont in Aedes aegypti Limits Infection with Dengue, Chikungunya, and Plasmodium. Cell., vol.139, n. 7, p. 1268-78, 2009. | pt_BR |
ISSN | 0092-8674 | |
URI | https://www.arca.fiocruz.br/handle/icict/13668 | |
Language | eng | pt_BR |
Publisher | Cell Press | pt_BR |
Rights | open access | pt_BR |
Title | A Wolbachia symbiont in Aedes aegypti limits infection with dengue, Chikungunya, and Plasmodium | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.cell.2009.11.042 | |
Abstract | Wolbachia are maternally inherited intracellular bacterial symbionts that are estimated to infect more than 60% of all insect species. While Wolbachia is commonly found in many mosquitoes it is absent from the species that are considered to be of major importance for the transmission of human pathogens. The successful introduction of a life-shortening strain of Wolbachia into the dengue vector Aedes aegypti that halves adult lifespan has recently been reported. Here we show that this same Wolbachia infection also directly inhibits the ability of a range of pathogens to infect this mosquito species. The effect is Wolbachia strain specific and relates to Wolbachia priming of the mosquito innate immune system and potentially competition for limiting cellular resources required for pathogen replication. We suggest that this Wolbachia-mediated pathogen interference may work synergistically with the life-shortening strategy proposed previously to provide a powerful approach for the control of insect transmitted diseases. | pt_BR |
Affilliation | University of Queensland. School of Biological Sciences. Brisbane, Australia/ Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | University of Queensland. School of Biological Sciences. Brisbane, Australia | pt_BR |
Affilliation | Queensland Institute of Medical Research. Post Office Royal Brisbane Hospital. Brisbane, Australia | pt_BR |
Affilliation | Queensland Institute of Medical Research. Post Office Royal Brisbane Hospital. Brisbane, Australia | pt_BR |
Affilliation | Virology, Queensland Health Forensic and Scientific Services. Coopers Plains, Australia | pt_BR |
Affilliation | University of Queensland. School of Biological Sciences. Brisbane, Australia | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | University of Queensland. School of Chemical and Molecular Biosciences. Brisbane, Australia | pt_BR |
Affilliation | University of Queensland. School of Chemical and Molecular Biosciences. Brisbane, Australia | pt_BR |
Affilliation | University of Queensland. School of Biological Sciences. Brisbane, Australia/University of Western Sydney. Centre for Plants and the Environment, School of Natural Sciences. Penrith South DC, NSW, Australia | pt_BR |
Affilliation | Queensland Institute of Medical Research. Post Office Royal Brisbane Hospital. Brisbane, Australia | pt_BR |
Affilliation | University of Queensland. School of Biological Sciences. Brisbane, Australia | pt_BR |
Affilliation | Queensland Institute of Medical Research. Post Office Royal Brisbane Hospital. Brisbane, Australia | pt_BR |
Affilliation | University of Queensland. School of Biological Sciences. Brisbane, Australia | pt_BR |
Affilliation | Virology, Queensland Health Forensic and Scientific Services. Coopers Plains, Australia/niversity of Queensland. School of Chemical and Molecular Biosciences. Brisbane, Australia | pt_BR |
Affilliation | Queensland Institute of Medical Research. Post Office Royal Brisbane Hospital. Brisbane, Australia | pt_BR |
Affilliation | University of Queensland. School of Biological Sciences. Brisbane, Australia | pt_BR |
Subject | Humdisease | pt_BR |
Subject | Molimmuno | pt_BR |