Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/13438
Title: Revisiting the Posttherapeutic Cure Criterion in Chagas Disease: Time for New Methods, More Questions, Doubts, and Polemics or Time to Change Old Concepts?
Authors: Lana, Marta de
Martins Filho, Olindo Assis
Affilliation: Universidade Federal de Ouro Preto. Escola de Farmácia. Departamento de Análises Clínicas. Ouro Preto, MG, Brasil / Universidade Federal de Ouro Preto. Escola de Farmácia. Programas de Pós-Graduação em Ciências Biológicas (Núcleo de Pesquisas em Ciências Biológicas (NUPEB)) e Ciências Farmacêuticas (CiPHARMA). Ouro Preto, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil
Abstract: One of the most relevant issues beyond the effectiveness of etiological treatment of Chagas disease is the lack of consensual/feasible tools to identify and certify the definitive parasitological cure. Several methods of distinct natures (parasitological, serological, and molecular) have been continuously proposed and novel perspectives are currently under investigation. Although the simultaneous use of distinct tests may offer better contributions and advances, it also leads to controversies of interpretation, with lack of mutual consent of cure criterion amongst researchers and physicians. In fact, when distinct host compartments (blood/tissues) are evaluated and explored, novel questions may arise due to the nature and sensitivity limit of each test. This short analytical review intends to present a chronological and critical overview and discuss the state-of-the-art distinct devices available for post therapeutic cure assessment in Chagas disease, their contributions, meanings, and interpretation, aiming to point out the major gaps and propose novel insight for future perspectives of post therapeutic management of Chagas disease patients.
Keywords: Chagas disease
Issue Date: 2015
Publisher: Hindawi Publishing Corporation
Citation: Lana, Marta de; Martins Filho, Olindo Assis. Revisiting the Posttherapeutic Cure Criterion in Chagas Disease: Time for New Methods, More Questions, Doubts, and Polemics or Time to Change Old Concepts? BioMed Research International, Vol. 2015, Article ID 652985, 2015.
DOI: 10.1155/2015/652985
ISSN: 2314-6141
Copyright: open access
Appears in Collections:CPqRR - Artigos de Periódicos

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