Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/13253
Title: Assessment of Galectin-3 Polymorphism in Subjects with Chronic Chagas Disease.
Authors: Cruz, Gabriela da Silva
Angelo, Ana Luiza Dias
Larocca, Ticiana Ferreira
Macedo, Carolina Thé
Rabelo, Márcia Noya
Correia, Luis Cláudio Lemos
Torreão, Jorge Andion
Souza, Bruno Solano de Freitas
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
Affilliation: Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil
Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil
Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil
Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: BACKGROUND: Galectin-3, a ß-galactoside binding lectin, has been described as a mediator of cardiac fibrosis in experimental studies and as a risk factor associated with cardiovascular events in subjects with heart failure. Previous studies have evaluated the genetic susceptibility to Chagas disease in humans, including the polymorphisms of cytokine genes, demonstrating correlations between the genetic polymorphism and cardiomyopathy development in the chronic phase. However, the relationship between the galectin-3 single nucleotide polymorphism (SNP) and phenotypic variations in Chagas disease has not been evaluated. OBJECTIVE: The present study aimed to determine whether genetic polymorphisms of galectin-3 may predispose to the development of cardiac forms of Chagas disease. METHODS: Fifty-five subjects with Chagas disease were enrolled in this observational study. Real-time polymerase chain reaction (PCR) was used for genotyping the variants rs4644 and rs4652 of the galectin-3 gene. RESULTS: For the SNP rs4644, the relative risk for the cardiac form was not associated with the genotypes AA (OR = 0.79, p = 0.759), AC (OR = 4.38, p = 0.058), or CC (OR = 0.39, p = 0.127). Similarly, for the SNP rs4652, no association was found between the genotypes AA (OR = 0.64, p = 0.571), AC (OR = 2.85, p = 0.105), or CC (OR = 0.49, p = 0.227) and the cardiac form of the disease. CONCLUSION: Our results showed no association between the different genotypes for both SNPs of the galectin-3 gene and the cardiac form of Chagas disease.
Keywords: Chagas Disease
Galectin 3
Heart Failure
Polymorphism
Genetic
Chagas Cardiomyopathy
Issue Date: 2015
Publisher: Sociedade Brasileira de Cardiologia
Citation: CRUZ, G. S. et al. Assessment of Galectin-3 Polymorphism in Subjects with Chronic Chagas Disease. Arquivo Brasileiro de Cardiologia, v. 105, n. 5, p. 472-478, 2015.
ISSN: 1678-4170
10.5935/abc.20150105
Copyright: open access
Appears in Collections:IGM - Artigos de Periódicos

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