Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/12956
Title: Correlation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patients.
Authors: Barbosa, Theolis Costa
Arruda, Sérgio Marcos
Chalhoub, Marcelo
Oliveira, Fabiano
Melo Junior, José F
Fidelis, Ramon
N Neto, Antônio
Barbosa Junior, Aryon de Almeida
Barral Netto, Manoel
Affilliation: Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Baiana para o Desenvolvimento das Ciências. Salvador, BA, Brasil
Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina.. Salvador, BA, Brasil
Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina.. Salvador, BA, Brasil
Abstract: In order to identify mediators involved in immune-mediated disease regression, the pleural cytokine and histopathological profile was evaluated in tuberculous pleurisy patients with varied disease duration and clinical presentation, previous to chemotherapy. Interleukin (IL)-10, interferon (IFN)-g and tumor necrosis factor (TNF) levels in pleural fluids were shown to decrease with disease time. IL-10 was positively correlated with IFN-g, TNF and necrosis area in pleural sections. To parallel these findings with disease regression, individuals showing fever, anorexia, and progressive exudate in the pleural cavity (active disease) were compared with patients without symptoms and with a decrease in exudate volume (regressive disease). IFN-g and TNF levels were lower in regressive disease, as well as reduced necrosis area in pleural sections. Our results indicate that tissue destruction and a prominent Th1 response mark the early phase of tuberculous pleurisy and suggest that downmodulation of this response, with the possible participation of IL-10, is associated with disease resolution
Keywords: Tuberculosis
Pleural
Disease progression
Cytokines
Pathology
DeCS: Fibrose/metabolismo
Interleucina-10/metabolismo
Necrose/metabolismo
Tuberculose Pleural/metabolismo
Adolescente
Adulto
Idoso
Progressão da Doença
Feminino
Humano
Masculino
Meia-Idade
Issue Date: 2006
Publisher: Elsevier
Citation: BARBOSA, T. C. et al. Correlation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patients. Microbes and Infection, v. 8, p. 889-897, 2006.
DOI: 10.1016/j.micinf.2005.10.017
ISSN: 1286-4579
Copyright: open access
Appears in Collections:IGM - Artigos de Periódicos

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