Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/12941
Title: Morphological signs of cirrhosis regression. Experimental observations on carbon tetrachloride-induced liver cirrhosis of rats.
Authors: Vinicius, Igor Di
Baptista, Ana Paula
Barbosa Junior, Aryon de Almeida
Andrade, Zilton de Araújo
Affilliation: Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil
Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil
Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil
Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil
Abstract: Regression of hepatic cirrhosis is a controversial issue. Recently, a list of histopathological features, observed in human material, was suggested as a hallmark of cirrhosis in the process of regression. An investigation for the presence of these morphologic features was performed at monthly intervals in rats with proved carbon tetrachloride (CCl4)- induced cirrhosis over a period of 9 months following discontinuation of treatment, using sequential liver biopsies. Within the first 4 months, features of the ‘‘hepatic repair complex’’ were identified, together with the enlargement of the hepatic nodules and thinning of the fibrous septa. Subsequent to the 4 months, the histological picture, composed of large and inconspicuous nodules and delimited by thin and frequently incomplete fibrous septa ‘‘incomplete septal cirrhosis’’, appeared to be stabilized. These fibrous septa, when injected with India ink from the portal trunk, presented blood vessels that were seen to drain directly into the sinusoids. These findings suggested that when the cause of cirrhosis is removed, the liver may adapt itself to a new and permanent structure, probably compatible with normal or near-normal function, which may render hepatic cirrhosis clinically, although not morphologically, reversible. r 2005 Elsevier GmbH. All rights reserved.
Keywords: Hepatic fibrosis
Cirrhosis
Cirrhosis reversibility
DeCS: Cirrose Hepática Experimental/patologia
Fígado/patologia
Recuperação de Função Fisiológica
Animais
Marcadores Biológicos/metabolismo
Biópsia
Tetracloreto de Carbono
Modelos Animais de Doenças
Feminino
Imunofluorescência
Hepatócitos/metabolismo
Hidroxiprolina/metabolismo
Cirrose Hepática Experimental/metabolismo
Masculino
Issue Date: 2005
Publisher: Elsevier
Citation: VINICIUS, I. di et al. Morphological signs of cirrhosis regression. Experimental observations on carbon tetrachloride-induced liver cirrhosis of rats. Pathology, Research and Practice, v. 201, n. 6, p. 449-456, 2005.
DOI: 10.1016/j.prp.2005.05.009
ISSN: 0344-0338
Copyright: open access
Appears in Collections:IGM - Artigos de Periódicos

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