Author | Araújo, Izabella Rodrigues | |
Author | Ferrari, Teresa Cristina Abreu | |
Author | Carvalho, Andréa Teixeira de | |
Author | Azevedo, Ana Carolina Campi | |
Author | Rodrigues, Luan Vieira | |
Author | Guimarães Júnior, Milton Henriques | |
Author | Barros, Thais Lins Souza | |
Author | Gelape, Cláudio Léo | |
Author | Sousa, Giovane Rodrigo | |
Author | Nunes, Maria Carmo Pereira | |
Access date | 2016-02-22T18:51:07Z | |
Available date | 2016-02-22T18:51:07Z | |
Document date | 2015 | |
Citation | ARAÚJO, Izabella Rodrigues et al. Cytokine Signature in Infective Endocarditis. PLoS ONE, vol. 10, n. 7, p. e0133631, 2015. | pt_BR |
ISSN | 1932-6203 | |
URI | https://www.arca.fiocruz.br/handle/icict/12788 | |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Title | Cytokine Signature in Infective Endocarditis | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pone.0133631 | |
Abstract | Infective endocarditis (IE) is a severe disease with high mortality rate. Cytokines participate in its pathogenesis and may contribute to early diagnosis improving the outcome. This study aimed to evaluate the cytokine profile in IE. Serum concentrations of interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12 and tumor necrosis factor (TNF)-α were measured by cytometric bead array (CBA) at diagnosis in 81 IE patients, and compared with 34 healthy subjects and 30 patients with non-IE infections, matched to the IE patients by age and gender. Mean age of the IE patients was 47±17 years (range, 15–80 years), and 40 (50%) were male. The IE patients had significantly higher serum concentrations of IL-1β, IL-6, IL-8, IL-10 and TNF-α as compared to the healthy individuals. The median levels of IL-1β, TNF-α and IL-12 were higher in the IE than in the non-IE infections group. TNF-α and IL-12 levels were higher in staphylococcal IE than in the non-staphylococcal IE subgroup. There was a higher proportion of both low IL-10 producers and high producers of IL-1β, TNF-α and IL-12 in the staphylococcal IE than in the non-staphylococcal IE subgroup. This study reinforces a relationship between the expression of proinflammatory cytokines, especially IL-1β, IL-12 and TNF-α, and the pathogenesis of IE. A lower production of IL-10 and impairment in cytokine network may reflect the severity of IE and may be useful for risk stratification. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Programa de Pós-Graduação em Infectologia e Medicina Tropical. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Programa de Pós-Graduação em Infectologia e Medicina Tropical. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Programa de Pós-Graduação em Infectologia e Medicina Tropical. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Programa de Pós-Graduação em Infectologia e Medicina Tropical. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Programa de Pós-Graduação em Infectologia e Medicina Tropical. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Cirurgia. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Programa de Pós-Graduação em Infectologia e Medicina Tropical. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Programa de Pós-Graduação em Infectologia e Medicina Tropical. Belo Horizonte, MG, Brasil | pt_BR |
Subject | Cytokines | pt_BR |
Subject | Inflammation | pt_BR |
Subject | Staphylococcus | pt_BR |
Subject | Endocarditis | pt_BR |
Subject | Biomarkers | pt_BR |
Subject | Staphylococcal infection | pt_BR |
Subject | Infectious disease control | pt_BR |
Subject | Immune response | pt_BR |