Author | Melgaço, Juliana Gil | |
Author | Morgado, Lucas Nóbrega | |
Author | Santiago, Marta Almeida | |
Author | Oliveira, Jaqueline Mendes de | |
Author | Lewis-Ximenez, Lia Laura | |
Author | Hasselmann, Bárbara | |
Author | Cruz, Oswaldo Gonçalves | |
Author | Pinto, Marcelo Alves | |
Author | Vitral, Claudia Lamarca | |
Access date | 2016-02-16T16:13:41Z | |
Available date | 2016-02-16T16:13:41Z | |
Document date | 2015 | |
Citation | MELGAÇO, Juliana Gil et al. A single dose of inactivated hepatitis A vaccine promotes HAV-specific memory cellular response similar to that induced by a natural infection. Vaccine, v. 33, n. 32, p. 3813-3820, July 2015. | pt_BR |
ISSN | 0264-410X | |
URI | https://www.arca.fiocruz.br/handle/icict/12738 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Hepatite A | pt_BR |
Subject in Portuguese | Vacinas | pt_BR |
Subject in Portuguese | Dose Única | pt_BR |
Title | A single dose of inactivated hepatitis A vaccine promotes HAV-specific memory cellular response similar to that induced by a natural infection | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.vaccine.2015.06.099 | |
Abstract | Based on current studies on the effects of single dose vaccines on antibody production, Latin American countries have adopted a single dose vaccine program. However, no data are available on the activation of cellular response to a single dose of hepatitis A. Our study investigated the functional reactivity of the memory cell phenotype after hepatitis A virus (HAV) stimulation through administration of the first or second dose of HAV vaccine and compared the response to that of a baseline group to an initial natural infection. Proliferation assays showed that the first vaccine dose induced HAV-specific cellular response; this response was similar to that induced by a second dose or an initial natural infection. Thus, from the first dose to the second dose, increase in the frequencies of classical memory B cells, TCD8 cells, and central memory TCD4 and TCD8 cells were observed. Regarding cytokine production, increased IL-6, IL-10, TNF, and IFN levels were observed after vaccination. Our findings suggest that a single dose of HAV vaccine promotes HAV-specific memory cell response similar to that induced by a natural infection. The HAV-specific T cell immunity induced by primary vaccination persisted independently of the protective plasma antibody level. In addition, our results suggest that a single dose immunization system could serve as an alternative strategy for the prevention of hepatitis A in developing countries. | pt_BR |
Affilliation | Universidade Federal Fluminense. Departamento de Microbiologia e Parasitologia. Niterói, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Departamento de Microbiologia e Parasitologia. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Bio-Manguinhos. Laboratório de Tecnologia Diagnóstica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Ambulatório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Ambulatório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Departamento de Microbiologia e Parasitologia. Niterói, RJ, Brasil. | pt_BR |
Subject | Hepatitis A vaccine | pt_BR |
Subject | Single dose | pt_BR |
Subject | Central memory cells | pt_BR |
Subject | Effector memory cells | pt_BR |
Subject | Cellular response | pt_BR |