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A SIDE-BY-SIDE COMPARISON OF T CELL REACTIVITY TO FIFTY-NINE MYCOBACTERIUM TUBERCULOSIS ANTIGENS IN DIVERSE POPULATIONS FROM FIVE CONTINENTS
Author
Carpenter, Chelsea
Sidney, John
Kolla, Ravi
Nayak, Kaustuv
Tomiyama, Helena
Tomiyama, Claudia
Padilla, Oscar A.
Rozot, Virginie
Ahamed, Syed F.
Ponte, Carlos
Rolla, Valeria
Antas, Paulo R.
Chandele, Anmol
Kenneth, John
Laxmi, Seetha
Makgotlho, Edward
Vanini, Valentina
Ippoliyo, Giuseppe
Kazanova, Alexandra S.
Panteleev, Alexander V.
Hanekom, Willem
Mayanja-Kizza, Harriet
Lewinsohn, David
Saito, Mayuko
McElrath, M. Juliana
Boom, W. Henri
Goletti, Delia
Gilman, Robert
Lyadova, Irina V.
Scriba, Thomas J.
Kallas, Esper Georges
Murali-Krishna, Kaja
Sette, Alessandro
Arlehamn, Cecilia S. Lindestam
Sidney, John
Kolla, Ravi
Nayak, Kaustuv
Tomiyama, Helena
Tomiyama, Claudia
Padilla, Oscar A.
Rozot, Virginie
Ahamed, Syed F.
Ponte, Carlos
Rolla, Valeria
Antas, Paulo R.
Chandele, Anmol
Kenneth, John
Laxmi, Seetha
Makgotlho, Edward
Vanini, Valentina
Ippoliyo, Giuseppe
Kazanova, Alexandra S.
Panteleev, Alexander V.
Hanekom, Willem
Mayanja-Kizza, Harriet
Lewinsohn, David
Saito, Mayuko
McElrath, M. Juliana
Boom, W. Henri
Goletti, Delia
Gilman, Robert
Lyadova, Irina V.
Scriba, Thomas J.
Kallas, Esper Georges
Murali-Krishna, Kaja
Sette, Alessandro
Arlehamn, Cecilia S. Lindestam
Affilliation
La Jolla Institute for Allergy and Immunology. Department of Vaccine Discovery. La Jolla, USA.
La Jolla Institute for Allergy and Immunology. Department of Vaccine Discovery. La Jolla, USA.
La Jolla Institute for Allergy and Immunology. Department of Vaccine Discovery. La Jolla, USA.
International Centre for Genetic Engineering and Biotechnology. ICGEB-Emory Vaccine Centre. New Delhi, India.
Universidade de São Paulo. Escola de Medicina. Divisão de Imunologia Clínica e Alergia. São Paulo, SP, Brasil.
Universidade de São Paulo. Escola de Medicina. Divisão de Imunologia Clínica e Alergia. São Paulo, SP, Brasil.
Universidade de São Paulo. Escola de Medicina. Divisão de Imunologia Clínica e Alergia. São Paulo, SP, Brasil.
Institute of Infectious Disease and Molecular Medicine. South African Tuberculosis Vaccine Initiative. Cape Town, South Africa / University of Cape Town. Department of Pediatrics and Child Health. Cape Town, South Africa.
St. John's National Academy of Sciences. St. John's Research Institute. Division of Infectious Diseases. Bangaluru, Karnataka, India.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil.
International Centre for Genetic Engineering and Biotechnology. ICGEB-Emory Vaccine Centre. New Delhi, India.
St. John's National Academy of Sciences. St. John's Research Institute. Division of Infectious Diseases. Bangaluru, Karnataka, India.
St. John's National Academy of Sciences. St. John's Medical College Hospital. Department of Transfusion Medicine and Immunohematology. Bangalaru, India.
Institute of Infectious Disease and Molecular Medicine. South African Tuberculosis Vaccine Initiative. Cape Town, South Africa / University of Cape Town. Department of Pediatrics and Child Health. Cape Town, South Africa.
National Institute for Infectious Diseases. Department of Epidemiology and Preclinical Research. h Translational Research Unit. Rome, Italy.
National Institute for Infectious Diseases. Department of Epidemiology and Preclinical Research. h Translational Research Unit. Rome, Italy.
Federal State Budgetary Scientific Institution “Central Tuberculosis Research Institute”. Department of Immunology. Moscow, Russia.
Federal State Budgetary Scientific Institution “Central Tuberculosis Research Institute”. Department of Immunology. Moscow, Russia.
Institute of Infectious Disease and Molecular Medicine. South African Tuberculosis Vaccine Initiative. Cape Town, South Africa / University of Cape Town. Department of Pediatrics and Child Health. Cape Town, South Africa.
University. Faculty of Medicine. College of Health Sciences. Department of Medicine. Kampala, Uganda.
Oregon Health and Science University. Portland, USA.
Johns Hopkins University. Bloomberg School of Public Health. Baltimore, USA / Universidad Peruana Caytano Hereida. Lima, Peru / Tohoku University. Departmento of Virology. Sendai,Japan..
Fred Hutchinson Cancer Research Center. Vaccine and Infectious Disease Division. Seattle, USA.
Case Western Reserve University School of Medicine. Department of Medicine. Tuberculosis Research Unit. Cleveland, USA.
National Institute for Infectious Disease. Department of Epidemiology and Preclinical Research. Translational Research Unit. Rome , Italy.
Johns Hopkins University. Bloomberg School of Public Health. Baltimore, USA / Universidad Peruana Caytano Hereida. Lima, Peru.
Federal State Budgetary Scientific Institution “Central Tuberculosis Research Institute”. Department of Immunology. Moscow, Russia.
Institute of Infectious Disease and Molecular Medicine. South African Tuberculosis Vaccine Initiative. Cape Town, South Africa / University of Cape Town. Department of Pediatrics and Child Health. Cape Town, South Africa.
Institute of Infectious Disease and Molecular Medicine. South African Tuberculosis Vaccine Initiative. Cape Town, South Africa / University of Cape Town. Department of Pediatrics and Child Health. Cape Town, South Africa.
Universidade de São Paulo. Escola de Medicina. Divisão de Imunologia Clínica e Alergia. São Paulo, SP, Brasil.
International Centre for Genetic Engineering and Biotechnology.ICGEB-Emory Vaccine Centre. New Delhi, India / Emory Vaccine Cent. Atlanta, GA, USA / Emory University. Department of Pediatrics. Atlanta, GA, USA.
La Jolla Institute for Allergy and Immunology. Department of Vaccine Discovery. La Jolla, USA.
La Jolla Institute for Allergy and Immunology. Department of Vaccine Discovery. La Jolla, USA.
La Jolla Institute for Allergy and Immunology. Department of Vaccine Discovery. La Jolla, USA.
La Jolla Institute for Allergy and Immunology. Department of Vaccine Discovery. La Jolla, USA.
International Centre for Genetic Engineering and Biotechnology. ICGEB-Emory Vaccine Centre. New Delhi, India.
Universidade de São Paulo. Escola de Medicina. Divisão de Imunologia Clínica e Alergia. São Paulo, SP, Brasil.
Universidade de São Paulo. Escola de Medicina. Divisão de Imunologia Clínica e Alergia. São Paulo, SP, Brasil.
Universidade de São Paulo. Escola de Medicina. Divisão de Imunologia Clínica e Alergia. São Paulo, SP, Brasil.
Institute of Infectious Disease and Molecular Medicine. South African Tuberculosis Vaccine Initiative. Cape Town, South Africa / University of Cape Town. Department of Pediatrics and Child Health. Cape Town, South Africa.
St. John's National Academy of Sciences. St. John's Research Institute. Division of Infectious Diseases. Bangaluru, Karnataka, India.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil.
International Centre for Genetic Engineering and Biotechnology. ICGEB-Emory Vaccine Centre. New Delhi, India.
St. John's National Academy of Sciences. St. John's Research Institute. Division of Infectious Diseases. Bangaluru, Karnataka, India.
St. John's National Academy of Sciences. St. John's Medical College Hospital. Department of Transfusion Medicine and Immunohematology. Bangalaru, India.
Institute of Infectious Disease and Molecular Medicine. South African Tuberculosis Vaccine Initiative. Cape Town, South Africa / University of Cape Town. Department of Pediatrics and Child Health. Cape Town, South Africa.
National Institute for Infectious Diseases. Department of Epidemiology and Preclinical Research. h Translational Research Unit. Rome, Italy.
National Institute for Infectious Diseases. Department of Epidemiology and Preclinical Research. h Translational Research Unit. Rome, Italy.
Federal State Budgetary Scientific Institution “Central Tuberculosis Research Institute”. Department of Immunology. Moscow, Russia.
Federal State Budgetary Scientific Institution “Central Tuberculosis Research Institute”. Department of Immunology. Moscow, Russia.
Institute of Infectious Disease and Molecular Medicine. South African Tuberculosis Vaccine Initiative. Cape Town, South Africa / University of Cape Town. Department of Pediatrics and Child Health. Cape Town, South Africa.
University. Faculty of Medicine. College of Health Sciences. Department of Medicine. Kampala, Uganda.
Oregon Health and Science University. Portland, USA.
Johns Hopkins University. Bloomberg School of Public Health. Baltimore, USA / Universidad Peruana Caytano Hereida. Lima, Peru / Tohoku University. Departmento of Virology. Sendai,Japan..
Fred Hutchinson Cancer Research Center. Vaccine and Infectious Disease Division. Seattle, USA.
Case Western Reserve University School of Medicine. Department of Medicine. Tuberculosis Research Unit. Cleveland, USA.
National Institute for Infectious Disease. Department of Epidemiology and Preclinical Research. Translational Research Unit. Rome , Italy.
Johns Hopkins University. Bloomberg School of Public Health. Baltimore, USA / Universidad Peruana Caytano Hereida. Lima, Peru.
Federal State Budgetary Scientific Institution “Central Tuberculosis Research Institute”. Department of Immunology. Moscow, Russia.
Institute of Infectious Disease and Molecular Medicine. South African Tuberculosis Vaccine Initiative. Cape Town, South Africa / University of Cape Town. Department of Pediatrics and Child Health. Cape Town, South Africa.
Institute of Infectious Disease and Molecular Medicine. South African Tuberculosis Vaccine Initiative. Cape Town, South Africa / University of Cape Town. Department of Pediatrics and Child Health. Cape Town, South Africa.
Universidade de São Paulo. Escola de Medicina. Divisão de Imunologia Clínica e Alergia. São Paulo, SP, Brasil.
International Centre for Genetic Engineering and Biotechnology.ICGEB-Emory Vaccine Centre. New Delhi, India / Emory Vaccine Cent. Atlanta, GA, USA / Emory University. Department of Pediatrics. Atlanta, GA, USA.
La Jolla Institute for Allergy and Immunology. Department of Vaccine Discovery. La Jolla, USA.
La Jolla Institute for Allergy and Immunology. Department of Vaccine Discovery. La Jolla, USA.
Abstract
We compared T cell recognition of 59 prevalently recognized Mycobacterium tuberculosis (MTB) antigens in individuals latently infected with MTB (LTBI), and uninfected individuals with previous BCG vaccination, from nine locations and populations with different HLA distribution, MTB exposure rates, and standards of TB care. This comparison revealed similar response magnitudes in diverse LTBI and BCG-vaccinated cohorts and significant correlation between responses in LTBIs from the USA and other locations. Many antigens were uniformly recognized, suggesting suitability for inclusion in vaccines targeting diverse populations. Several antigens were similarly immunodominant in LTBI and BCG cohorts, suggesting applicability for vaccines aimed at boosting BCG responses. The panel of MTB antigens will be valuable for characterizing MTB-specific CD4 T cell responses irrespective of ethnicity, infecting MTB strains and BCG vaccination status. Our results illustrate how a comparative analysis can provide insight into the relative immunogenicity of existing and novel vaccine candidates in LTBIs.
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