Author | Teles, Rosane M. B. | |
Author | Graeber, Thomas G. | |
Author | Krutzik, Stephan R. | |
Author | Montoya, Dennis | |
Author | Schenk, Mirjam | |
Author | Lee, Delphine J. | |
Author | Komisopoulou, Evangelia | |
Author | Kelly-Scumpia, Kindra | |
Author | Chun, Rene | |
Author | Iyer, Shankar S. | |
Author | Sarno, Euzenir Nunes | |
Author | Rea, Thomas H. | |
Author | Hewison, Martin | |
Author | Adams, John S. | |
Author | Popper, Stephen J. | |
Author | Relman, David A. | |
Author | Stenger, Steffen | |
Author | Bloom, Barry R. | |
Author | Cheng, Genhong | |
Author | Modlin, Robert L. | |
Access date | 2016-01-21T14:06:52Z | |
Available date | 2016-01-21T14:06:52Z | |
Document date | 2013 | |
Citation | TELES, Rosane M. B. et al. Type I Interferon Suppresses Type II Interferon–Triggered Human Anti-Mycobacterial Responses. Science, v.339, p.1448-1453, March 2013. | pt_BR |
ISSN | 1095-9203 | |
URI | https://www.arca.fiocruz.br/handle/icict/12579 | |
Language | eng | pt_BR |
Publisher | American Association for the Advancement of Science | pt_BR |
Rights | open access | |
Title | Type I Interferon Suppresses Type II Interferon–Triggered Human Anti-Mycobacterial Responses | pt_BR |
Type | Article | |
DOI | 10.1126/science.1233665 | |
Abstract | Type I interferons (IFN-a and IFN-b) are important for protection against many viral infections,
whereas type II interferon (IFN-g) is essential for host defense against some bacterial and parasitic
pathogens. Study of IFN responses in human leprosy revealed an inverse correlation between IFN-b
and IFN-g gene expression programs. IFN-g and its downstream vitamin D–dependent antimicrobial
genes were preferentially expressed in self-healing tuberculoid lesions and mediated antimicrobial
activity against the pathogen Mycobacterium leprae in vitro. In contrast, IFN-b and its downstream
genes, including interleukin-10 (IL-10), were induced in monocytes by M. leprae in vitro and
preferentially expressed in disseminated and progressive lepromatous lesions. The IFN-g–induced
macrophage vitamin D–dependent antimicrobial peptide response was inhibited by IFN-b and by
IL-10, suggesting that the differential production of IFNs contributes to protection versus pathogenesis
in some human bacterial infections. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Division of Dermatology. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. Department of Molecular and Medical Pharmacology. California NanoSystems Institute. Johnson Comprehensive Cancer Center. Institute for Molecular Medicine. Crump Institute for Molecular Imaging. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Division of Dermatology. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Division of Dermatology. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Division of Dermatology. Los Angeles, CA, USA. | pt_BR |
Affilliation | John Wayne Cancer Institute. Department of Translational Immunology. Santa Monica, CA, USA. | pt_BR |
Affilliation | University of California. Department of Molecular and Medical Pharmacology. California NanoSystems Institute. Johnson Comprehensive Cancer Center. Institute for Molecular Medicine. Crump Institute for Molecular Imaging. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Division of Dermatology. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. UCLA/Orthopedic Hospital Department of Orthopedic Surgery. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Department of Microbiology, Immunology and Molecular Genetics. Los Angeles, CA, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Ri de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | University of Southern California School of Medicine. Department of Dermathology. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. UCLA/Orthopedic Hospital Department of Orthopedic Surgery. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. UCLA/Orthopedic Hospital Department of Orthopedic Surgery. Los Angeles, CA, USA. | pt_BR |
Affilliation | Stanford University School of Medicine. Department of Microbiology and Immunology. Department of Medicine. Stanford, CA, USA . | pt_BR |
Affilliation | Stanford University School of Medicine. Department of Microbiology and Immunology. Department of Medicine. Stanford, CA, USA / 9Veterans Affairs Palo Alto Health Care System. Palo Alto, CA, USA. | pt_BR |
Affilliation | University Hospital of Ulm. Institute for Medical Microbiology and Hygiene. Germany. | pt_BR |
Affilliation | Harvard School of Public Health. Boston, MA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Department of Microbiology, Immunology and Molecular Genetics. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Division of Dermatology. Los Angeles, CA, USA / University of California. David Geffen School of Medicine. Department of Microbiology, Immunology and Molecular Genetics. Los Angeles, CA, USA. | pt_BR |
Subject | Type I interferons (IFN-a and IFN-b) | pt_BR |
Subject | type II interferon (IFN-g) | pt_BR |
Subject | Leprosy | pt_BR |
Subject | Anti-Mycobacterial | pt_BR |
Subject | Mycobacterium leprae | pt_BR |
DeCS | Mycobacterium leprae | pt_BR |
DeCS | Hanseniase | pt_BR |
DeCS | Interferon Tipo I | pt_BR |
DeCS | Interferon gama | pt_BR |