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https://www.arca.fiocruz.br/handle/icict/12562
EVALUATION OF ANTI-INFLAMMATORY, ANTIANGIOGENIC AND ANTIPROLIFERATIVE ACTIVITIES OF ARRABIDAEA CHICA CRUDE EXTRACTS
Angiogenesis
Cytotoxic activity
Apoptosis
Inflammation
traditional medicine
Author
Affilliation
Universidade Estadual de Santa Cruz. Departamento de Ciências Agrárias e Ambientais. Ilhéus, BA, Brasil
Universidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Instituto de Química. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Instituto de Química. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais. Instituto de Química. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Instituto de Química. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Instituto de Química. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais. Instituto de Química. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil
Abstract
Traditional medicine abstract Ethnopharmacological relevance: Arrabidaea chica (Bignoniacea) has been used in popular medicine in Brazil to treat inflammation, skin diseases and leukemia. This work aimed to investigate the antiinflammatory and antitumoral activities of the A. chica aqueous (AE) and ethanol (EE) extracts. Materials and methods: The murine sponge model was used to evaluate the anti-inflammatory and antiangiogenic activities of AE and EE. Accumulation of neutrophil and macrophage in the implants were determined by assaying myeloperoxidase and N-acetyl-glucosaminidase activities and the neovascularization evaluated by the amount of hemoglobin present in the implant using the Drabkin method. The antitumoral activity was evaluated using the MTT colorimetric method against Jurkat, HL60 and MCF-7 cells. Semi-purified fractions F1-F4 from the EE extract were obtained by a liquid–liquid solvent extraction method and their in vitro anti-proliferative effects were also investigated. Results: Ethanol and aqueous extracts of A. chica decreased neutrophil accumulation and hemoglobin content in the sponge implants without altering the level of cytokines (IL-2, IL- 4, IL-5, IFN-γ, TNF-α and VEGF) and the albumin/globulin ratio in the serum of treated animals. There was no sign of toxicity (clinical, laboratory or histopathology). The ethanol extract presented antiproliferative activity (IC50 21.5– 36.3 mg/mL) against HL60 and Jurkat cell lineages and proapoptotic activity at 50 mg/mL in HL60 cells. The fraction F1 also demonstrated significant antiproliferative activity (IC50 38.5 mg/mL) and proapoptotic activity against HL60 cells in a dose dependent manner. Conclusions: Aqueous and ethanol extracts of A. chica attenuate the inflammatory and angiogenic components of the subcutaneous fibrovascular tissue induced by the synthetic matrix in mice. In addition, the ethanol extract from Arrabidaea chica and its fraction F1 presented in vitro antiproliferative activity and could be useful for developing potential chemopreventive substances.
Keywords
Arrabidaea chicaAngiogenesis
Cytotoxic activity
Apoptosis
Inflammation
traditional medicine
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