Author | Rodrigues, Katia F. | |
Author | Costa, Gisela L. | |
Author | Carvalho, Meriane P. | |
Author | Epifânio, Rosângela de A. | |
Access date | 2016-01-05T11:52:56Z | |
Available date | 2016-01-05T11:52:56Z | |
Document date | 2005 | |
Citation | Rodrigues, Katia F. et al. Evaluation of extracts produced by some tropical fungi as potential cholinesterase inhibitors. World Journal of Microbiology and Biotechnology, v. 21, p. 1617-1621, 2005. | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/12474 | |
Language | eng | pt_BR |
Publisher | Springer Plus | pt_BR |
Rights | restricted access | |
Title | Evaluation of extracts produced by some tropical fungi as potential cholinesterase inhibitors | pt_BR |
Type | Article | |
DOI | 10.1007/s11274-005-8344-5 | |
Abstract | Extracts of culture of fungal taxa belonging to Chaetomiun sp., Guignardia mangiferae, Pestalotiopsis guepinii, Phomopsis sp., Physalospora sp., and sterile mycelium isolated as endophytes from leaves of members of the plant fafmilies Anacardiaceae, Leguminosae and Palmae, and seven different species of Penicillium isolated from insects were tested for their in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activity using Wllman´s colorimetric method adapted for thin layer chromotherapy. The results showed hig rate of cholinesterase inhibitory activity, with the best result being obtained with Penicillium extracts, indicating that they might represent a valuable source for pharmaceutical applications and are worthy of further study. | en |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Micologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Micologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Instituto de Química. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Instituto de Química. Niterói, RJ, Brasil. | pt_BR |
Subject | Alzheimer´s disease | en |
Subject | Butyrylcholinesterase | en |
Subject | Endophytes | en |
Subject | Penicillium | en |
Subject | TLC bioautography | en |
Subject | Acetylcholinesterase | en |