Author | Paiva, Rojane de Oliveira | |
Author | Kneipp, Lucimar Ferreira | |
Author | Reis, Camila Moretto dos | |
Author | Echevarria, Aurea | |
Access date | 2015-08-19T13:49:22Z | |
Available date | 2015-08-19T13:49:22Z | |
Document date | 2015 | pt_BR |
Citation | PAIVA, Rojane de Oliveira: et al. Mesoionic compounds with antifungal activity against Fusarium verticillioides. BMC Microbiology, v.15:11, 8p, 2015. | pt_BR |
ISSN | 1471-2180 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/11496 | |
Language | eng | pt_BR |
Publisher | BioMed Central | pt_BR |
Rights | open access | pt_BR |
Title | Mesoionic compounds with antifungal activity against Fusarium verticillioides | pt_BR |
Type | Article | pt_BR |
DOI | 10.1186/s12866-015-0340-9 | pt_BR |
Abstract | Background: Fungi contaminate the food of humans and animals, are a risk to health, and can cause financial
losses. In this work, the antifungal activities of 16 mesoionic compounds (MI 1–16) were evaluated against
mycotoxigenic fungi, including Aspergillus spp., Fusarium verticillioides and Penicillium citrinum. Furthermore, the
decreased ergosterol in the total lipid content of Fusarium verticillioides was investigated.
Results: F. verticillioides was the most sensitive fungus to the mesoionic compounds. Among the evaluated compounds,
MI-11 and MI-16 presented higher antifungal effects against F. verticillioides, with MIC values of 7.8 μg/ml, and MI-2 and
MI-3 followed, with MICs of 15.6 μg/ml. The most active compounds were those with heterocyclic ring phenyl groups
substituted by electron donor moieties (MI-11 and MI-16). Among some compounds with higher activity (MI-2, MI-11
and MI-16), decreased ergosterol content in the total lipid fraction of F. verticillioides was demonstrated. MI-2 reduced
the ergosterol content approximately 40% and 80% at concentrations of 7.8 μg/ml and 15.6 μg/ml, respectively, and
MI-11 and MI-16 decreased the content by 30% and 50%, respectively, when at a concentration of 7.8 μg/ml.
Conclusion: These findings indicate that mesoionic compounds have significant antifungal activity against F. verticillioides. | pt_BR |
Affilliation | Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Taxonomia Bioquímica e Bioprospecção de Fungos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Taxonomia Bioquímica e Bioprospecção de Fungos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil. | pt_BR |
Subject | Mycotoxigenic fungi | pt_BR |
Subject | Mycotoxicology | pt_BR |
Subject | Mesoionic | pt_BR |
Subject | Antifungal activity | pt_BR |
Subject | Ergosterol | pt_BR |
DeCS | Ergosterol | pt_BR |
DeCS | Micotoxinas | pt_BR |
DeCS | Antifúngicos | pt_BR |