Author | Santiago, Iara Furtado | |
Author | Alves, Tania Maria Almeida | |
Author | Rabello, Ana Lucia Teles | |
Author | Sales Junior, Policarpo Ademar | |
Author | Romanha, Alvaro Jose | |
Author | Zani, Carlos Leomar | |
Author | Rosa, Carlos Augusto | |
Author | Rosa, Luiz Henrique | |
Access date | 2015-08-10T19:02:21Z | |
Available date | 2015-08-10T19:02:21Z | |
Document date | 2012 | |
Citation | SANTIAGO, Iara Furtado et al. Leishmanicidal and antitumoral activities of endophytic fungi associated with the Antarctic angiosperms Deschampsia antarctica Desv. and Colobanthus quitensis (Kunth) Bartl. Extremophiles. 2012, vol.16, n., 1, pp. 95-103 | pt_BR |
ISSN | 1431-0651 | |
URI | https://www.arca.fiocruz.br/handle/icict/11435 | |
Language | eng | pt_BR |
Publisher | Springer Complete Collection | pt_BR |
Rights | restricted access | pt_BR |
Title | Leishmanicidal and antitumoral activities of endophytic fungi associated with the Antarctic angiosperms Deschampsia antarctica Desv. and Colobanthus quitensis (Kunth) Bartl. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1007/s00792-011-0409-9 | |
Abstract | A total of 564 isolates of endophytic fungi were recovered from the plants Deschampsia antarctica and Colobanthus quitensis collected from Antarctica. The isolates were screened against parasites Leishmania amazonensis and Trypanosoma cruzi and against the human tumour cell lines. Of the 313 fungal isolates obtained from D. antarctica and 251 from C. quitensis, 25 displayed biological activity. Nineteen extracts displayed leishmanicidal activity, and six inhibited the growth of at least one tumour cell line. These fungi belong to 19 taxa of the genera Alternaria, Antarctomyces, Cadophora, Davidiella, Helgardia, Herpotrichia, Microdochium, Oculimacula, Phaeosphaeria and one unidentified fungus. Extracts of 12 fungal isolates inhibited the proliferation of L. amazonesis at a low IC50 of between 0.2 and 12.5 lg ml-1 . The fungus Phaeosphaeria herpotrichoides displayed only leishmanicidal activity with an IC50 of 0.2 lg ml-1 , which is equivalent to the inhibitory value of amphotericin B. The extract of Microdochium phragmitis displayed specific cytotoxic activity against the UACC-62 cell line with an IC50 value of 12.5 lg ml-1 . Our results indicate that the unique angiosperms living in Antarctica shelter an interesting bioactive fungal community that is able to produce antiprotozoal and antitumoral molecules. These molecules may be used to develop new leishmanicidal and anticancer drugs | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundaçao Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratorio de Quımica de Produtos Naturais. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundaçao Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratorio de Pesquisas Clınicas. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundaçao Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratorio de Parasitologia Celular e Molecular. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundaçao Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratorio de Parasitologia Celular e Molecular. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundaçao Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratorio de Quımica de Produtos Naturais. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil | pt_BR |
Subject | Antarctica Bioprospecting | pt_BR |
Subject | Leishmania Secondary | pt_BR |
Subject | metabolites Antitumoral activities | pt_BR |