Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/11174
Title: Patterns in Leptospira Shedding in Norway Rats (Rattus norvegicus) from Brazilian Slum Communities at High Risk of Disease Transmission.
Authors: Costa, Federico
Wunder, Elsio A
Oliveira, Daiana de
Bisht, Vimla
Rodrigues, Gorete
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
Begon, Mike
Childs, James E
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut, USA / University of Liverpool. Institute of Integrative Biology. United Kingdom
Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut, USA
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut, USA
Ministério da Saúde. Secretaria Municipal de Saúde. Centro de Controle do Zoonoses. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut, USA
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut, USA
University of Liverpool. Institute of Integrative Biology. United Kingdom
Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut, USA
Abstract: BACKGROUND: We address some critical but unknown parameters of individuals and populations of Norway rats (Rattus norvegicus) that influence leptospiral infection, maintenance and spirochetal loads shed in urine, which contaminates the environment ultimately leading to human infection. METHODOLOGY/PRINCIPAL FINDINGS: Our study, conducted in Salvador, Brazil, established the average load of leptospires in positive kidneys to be 5.9 x 106 per mL (range 3.1-8.2 x106) genome equivalents (GEq), similar to the 6.1 x 106 per ml (range 2.2-9.4 x106) average obtained from paired urines, with a significant positive correlation (R2=0.78) between the two. Based on bivariate and multivariate modeling, we found with both kidney and urine samples that leptospiral loads increased with the age of rats (based on the index of body length to mass), MAT titer and the presence of wounding/scars, and varied with site of capture. Some associations were modified by sex but trends were apparent. Combining with data on the demographic properties and prevalence of leptospiral carriage in rat populations in Salvador, we estimated that daily leptospiral loads shed in the urine of a population of 82 individuals exceeded 9.1 x 1010 leptospires. CONCLUSIONS/SIGNIFICANCE: These factors directly influence the risk of leptospiral acquisition among humans and provide essential epidemiological information linking properties of rat populations with risk of human infection.
keywords: Leptospirose
Leptospira
Infecção
Humanos
Transmissão
Rattus norvegicus
Ratos
Animal
Issue Date: 2015
Publisher: Public Library of Science
Citation: COSTA, F. et al. Patterns in Leptospira Shedding in Norway Rats (Rattus norvegicus) from Brazilian Slum Communities at High Risk of Disease Transmission. PLoS Neglected Tropical Diseases, v. 9, n. 6, p.e0003819, 2015
ISSN: 1935-2735
10.1371/journal.pntd.0003819
Copyright: open access
Appears in Collections:IGM - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Costa F Patterns....pdf326.25 kBAdobe PDFView/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.