Author | Postól, Edilberto | |
Author | Meyer, André Villanova | |
Author | Cardillo, Fabíola | |
Author | Alencar, Raquel de | |
Author | Pessina, Daniel Huber | |
Author | Nihei, Jorge Sadao | |
Author | Mariano, Mário | |
Author | Mengele Junior, José Orivaldo | |
Access date | 2015-06-18T17:21:29Z | |
Available date | 2015-06-18T17:21:29Z | |
Document date | 2008 | |
Citation | POSTÓL, E. et al. Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production. Immunology, v. 125, n. 2, p. 184-196, 2008. | pt_BR |
ISSN | 1365-2567 | |
URI | https://www.arca.fiocruz.br/handle/icict/10918 | |
Language | eng | pt_BR |
Publisher | Wiley | pt_BR |
Rights | open access | pt_BR |
Title | Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1111/j.1365-2567.2008.02835.x | |
Abstract | The role of natural killer (NK) T cells in the development of lupus-like
disease in mice is still controversial. We treated NZB/W mice with anti-
NK1.1 monoclonal antibodies (mAbs) and our results revealed that
administration of either an irrelevant immunoglobulin G2a (IgG2a) mAb
or an IgG2a anti-NK1.1 mAb increased the production of anti-dsDNA
antibodies in young NZB/W mice. However, the continuous administration
of an anti-NK1.1 mAb protected aged NZB/W mice from glomerular
injury, leading to prolonged survival and stabilization of the proteinuria.
Conversely, the administration of the control IgG2a mAb led to an aggravation
of the lupus-like disease. Augmented titres of anti-dsDNA in NZB/
W mice, upon IgG2a administration, correlated with the production of
BAFF/BLyS by dendritic, B and T cells. Treatment with an anti-NK1.1
mAb reduced the levels of interleukin-16, produced by T cells, in spleen
cell culture supernatants from aged NZB/W. Adoptive transfer of NK T
cells from aged to young NZB/W accelerated the production of antidsDNA
in recipient NZB/W mice, suggesting that NK T cells from aged
NZB/W are endowed with a B-cell helper activity. In vitro studies, using
purified NK T cells from aged NZB/W, showed that these cells provided
helper B-cell activity for the production of anti-dsDNA. We concluded
that NK T cells are involved in the progression of lupus-like disease in
mature NZB/W mice and that immunoglobulin of the IgG2a isotype has
an enhancing effect on antibody synthesis due to the induction of BAFF/
BLyS, and therefore have a deleterious effect in the NZB/W mouse
physiology. | pt_BR |
Affilliation | University of São Paulo. Heart Institute. Immunology Laboratory. São Paulo, SP, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | University of São Paulo. Heart Institute. Immunology Laboratory. São Paulo, SP, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of São Paulo. Department of Microbiology, Immunology and Parasitology. São Paulo, SP, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | BAFF/BLyS | pt_BR |
Subject | Fc receptor | pt_BR |
Subject | Interleukin-16 | pt_BR |
Subject | Natural killer T cells | pt_BR |
Subject | Systemic lupus erythematosus | pt_BR |
Subject | Toll-like recepto | pt_BR |
DeCS | Anticorpos Monoclonais/uso terapêutico | pt_BR |
DeCS | Fator Ativador de Células B/biossíntese | pt_BR |
DeCS | Imunoglobulina G/uso terapêutico | pt_BR |
DeCS | Nefrite Lúpica/prevenção & controle | pt_BR |
DeCS | Envelhecimento/imunologia | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Anticorpos Antinucleares/biossíntese | pt_BR |
DeCS | Anticorpos Monoclonais/imunologia | pt_BR |
DeCS | Antígenos Ly/imunologia | pt_BR |
DeCS | Células Cultivadas | pt_BR |
DeCS | Progressão da Doença | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Imunoglobulina G/imunologia | pt_BR |
DeCS | Interleucina-16/biossíntese | pt_BR |
DeCS | Células Matadoras Naturais/imunologia | pt_BR |
DeCS | Lipopolissacarídeos/imunologia | pt_BR |
DeCS | Fígado/imunologia | pt_BR |
DeCS | Nefrite Lúpica/imunologia | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Subfamília B de Receptores Semelhantes a Lectina de Células | pt_BR |
DeCS | Índice de Gravidade de Doença | pt_BR |
DeCS | Linfócitos T Auxiliares-Indutores/imunologia | pt_BR |