Author | Araújo, Alan Moreira de | |
Author | Reis, Eliana Almeida Gomes | |
Author | Athanazio, Daniel Abensur | |
Author | Ribeiro, Guilherme de Sousa | |
Author | Hagan, José Edward | |
Author | Araujo, Guilherme C | |
Author | Damião, Alcinéia Oliveira | |
Author | Couto, Nicolli S | |
Author | Ko, Albert Icksang | |
Author | Dutra, Alberto Noronha | |
Author | Reis, Mitermayer Galvão dos | |
Access date | 2015-05-25T13:54:00Z | |
Available date | 2015-05-25T13:54:00Z | |
Document date | 2014 | |
Citation | ARAÚJO, A. M. et al. Oxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis. American Journal of Tropical Medicine and Hygiene, v. 90, n. 4, p. 719-723, 2014. | pt_BR |
ISSN | 1476-1645 | |
URI | https://www.arca.fiocruz.br/handle/icict/10489 | |
Language | eng | pt_BR |
Publisher | American Society of Tropical Medicine and Hygiene | pt_BR |
Rights | open access | pt_BR |
Title | Oxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis. | pt_BR |
Type | Article | pt_BR |
DOI | 10.4269/ajtmh.13-0667 | |
Abstract | Leptospirosis is a zoonotic disease that causes severe manifestations such as Weil's disease and pulmonary hemorrhage syndrome. The aim of this study was to evaluate whether reactive oxygen species (ROS) production and antioxidant reduced glutathione (GSH) levels are related to complications in patients hospitalized with leptospirosis. The ROS production and GSH levels were measured in blood samples of 12 patients and nine healthy controls using chemiluminescence and absorbance assays. We found that ROS production was higher and GSH levels were lower in leptospirosis patients compared with healthy individuals. Among patients, GSH depletion was correlated with thrombocytopenia and elevated serum creatinine, whereas a strong positive correlation was observed between ROS production and elevated serum potassium. Additional investigation of the biological significance of ROS production and GSH levels is warranted as they may guide the development of novel adjuvant therapies for leptospirosis targeting oxidative stress | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brasil | pt_BR |
Affilliation | Yale University. New Haven. CT / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Yale University. New Haven. CT / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
DeCS | Lesão Renal Aguda/sangue | pt_BR |
DeCS | Glutationa/sangue | pt_BR |
DeCS | Leptospirose/sangue | pt_BR |
DeCS | Estresse Oxidativo | pt_BR |
DeCS | Espécies de Oxigênio Reativas/sangue | pt_BR |
DeCS | Trombocitopenia/sangue | pt_BR |
DeCS | Adolescente | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Marcadores Biológicos/sangue | pt_BR |
DeCS | Estudos de Casos e Controles | pt_BR |
DeCS | Estudos de Coortes | pt_BR |
DeCS | Creatinina/sangue | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Meia-Idade | pt_BR |
DeCS | Potássio/sangue | pt_BR |
DeCS | Índice de Gravidade de Doença | pt_BR |
DeCS | Adulto Jovem | pt_BR |