Author | Jarduli, Luciana Ribeiro | |
Author | Alves, Hugo Vicentin | |
Author | Santana, Fabiana Covolo de Souza | |
Author | Marcos, Elaine Valim Camarinha | |
Author | Pereira, Ana Carla | |
Author | Baptista, Ida Maria Foschiani Dias | |
Author | Fava, Vinicius Medeiros | |
Author | Mira, Marcelo Távora | |
Author | Moraes, Milton Ozório | |
Author | Virmond, Marcos da Cunha Lopes | |
Author | Visentainer, Jeane Eliete Laguila | |
Access date | 2015-05-22T18:42:42Z | |
Available date | 2015-05-22T18:42:42Z | |
Document date | 2014 | pt_BR |
Citation | JARDULI, Luciana Ribeiro et al. Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil. BMC Infectious Diseases, v.14:438, 8p, 2014. | pt_BR |
ISSN | 1471-2334 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/10467 | |
Language | eng | pt_BR |
Publisher | Biomed Central | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Hanseníase | pt_BR |
Title | Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil | pt_BR |
Type | Article | pt_BR |
DOI | 10.1186/1471-2334-14-438 | pt_BR |
Abstract | Background: The objective of this study was to investigate the association between KIR genes and the
immunopathogenesis of leprosy.
Methods: The types of KIR and HLA genes were evaluated by PCR-SSOP-Luminex in 408 patients with leprosy and
413 healthy individuals. Statistical analysis was performed using the Chi-square or Fisher’s exact test and stepwise
multivariate analysis.
Results: There was a higher frequency of activating KIR genes (KIR2DS1, 2DS2 and 3DS1) together with their HLA
ligands in the tuberculoid (TT) group as compared to the lepromatous leprosy (LL) group. KIR2DL2/2DL2-C1 was
more frequent in the patient, TT and LL groups than in the control group. Borderline patients presented a higher
frequency of inhibitory pairs when compared to the control group, and a higher frequency of activating pairs as
compared to the LL group. Multivariate analysis confirmed the associations and demonstrated that being a female
is a protective factor against the development of the disease per se and the more severe clinical form.
Conclusions: This study showed that activating and inhibitory KIR genes may influence the development of
leprosy – in particular, activating genes may protect against the more aggressive form of the disease – thereby
demonstrating the role of NK cells in the immunopathology of the disease. | pt_BR |
Affilliation | Universidade Estadual de Maringá. Departamento de Ciências Básicas da Saúde. Laboratório de Imunogenética. Maringá, PR, Brasil. | pt_BR |
Affilliation | Universidade Estadual de Maringá. Departamento de Ciências Básicas da Saúde. Laboratório de Imunogenética. Maringá, PR, Brasil. | pt_BR |
Affilliation | Instituto Lauro de Souza Lima. Bauru, SP, Brasil. | pt_BR |
Affilliation | Instituto Lauro de Souza Lima. Bauru, SP, Brasil. | pt_BR |
Affilliation | Instituto Lauro de Souza Lima. Bauru, SP, Brasil. | pt_BR |
Affilliation | Instituto Lauro de Souza Lima. Bauru, SP, Brasil. | pt_BR |
Affilliation | Pontifícia Universidade Católica do Paraná. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Pontifícia Universidade Católica do Paraná. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto Lauro de Souza Lima. Bauru, SP, Brasil. | pt_BR |
Affilliation | Universidade Estadual de Maringá. Departamento de Ciências Básicas da Saúde. Laboratório de Imunogenética. Maringá, PR, Brasil. | pt_BR |
Subject | Leprosy | pt_BR |
Subject | KIR genes | pt_BR |
Subject | NK cells | pt_BR |
Subject in Spanish | Lepra | pt_BR |
DeCS | Hanseníase | pt_BR |