| Author | Lima, Lyana Rodrigues | |
| Author | Almeida, Adilson José de | |
| Author | Tourinho, Renata dos Santos | |
| Author | Hasselmann, Bárbara | |
| Author | Ximenez, Lia Laura Lewis | |
| Author | Paula, Vanessa Salete de | |
| Access date | 2015-05-08T14:08:47Z | |
| Available date | 2015-05-08T14:08:47Z | |
| Document date | 2014 | pt_BR |
| Citation | LIMA, Lyana Rodrigues et al. Evidence of Hepatitis A Virus Person-to-Person Transmission in Household Outbreaks. Plos One, v.9, n.7, 6p, 2014. | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/10273 | |
| Language | eng | pt_BR |
| Publisher | Plos One | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Hepatite A | pt_BR |
| Subject in Portuguese | Hepatite Viral Humana | pt_BR |
| Title | Evidence of Hepatitis A Virus Person-to-Person Transmission in Household Outbreaks | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1371/journal.pone.0102925 | pt_BR |
| Abstract | The person-to-person transmission of the hepatitis A virus primarily occurs in enclosed spaces, particularly in the presence
of inadequate hygiene conditions and a high proportion of susceptible individuals. Thus, intimate family contact stands out
as a risk factor for HAV infection dissemination. The present study aimed to evaluate the occurrence of household HAV
transmission. Blood samples were collected from patients with hepatitis A (index cases) and their family members (contacts)
that were referred to an ambulatory care clinic specializing in viral hepatitis. A total of 97 samples were collected from 30
families with a confirmed hepatitis A case (index case). Serological and molecular techniques for the diagnosis of hepatitis A
were conducted on all samples. HAV infection (anti-HAV IgM + and/or HAV RNA +) was detected in 34.3% (23/67) of the
contacts; 34.3% (23/67) of the contacts were immune to HAV, and 31.4% (21/67) were susceptible. In the household
contacts, HAV immunity was significantly associated with older age; susceptibility to infection and HAV infection were
associated with younger age. Household outbreaks were detected in 16/30 families studied. Co-circulation of subgenotypes
IA and IB was found in the household outbreaks, and person-to-person transmission was evidenced in six of the household
outbreaks, with 100% homology between the index case and contact strains. The results demonstrated the relevance of
HAV household transmission, reaffirming the need for hepatitis A vaccine administration in susceptible contacts and
effective infection control procedures to prevent the extension of household outbreaks. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Ambulatório de Hepatites Virais. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée Guinle. Setor de Hematologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Ambulatório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Ambulatório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Hepatitis A Virus | pt_BR |
| Subject | Person-to-Person Transmission | pt_BR |
