Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/10243
Title: Immunohistochemical detection of Langerhans cells in dental granulomas and radicular cysts.
Authors: Santos, Luciano Cincurá Silva
Ramos, Eduardo Antônio Gonçalves
Gurgel, Clarissa Araújo Silva
Santana, Edmar José Borges de
Santos, Jean Nunes dos
Affilliation: Universidade Federal da Bahia. Escola de Dentista. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Histopatologia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Histopatologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Escola de Dentista. Laboratorio de Patologia Oral. Salvador, BA, Brasil
Universidade Federal da Bahia. Escola de Dentista. Laboratorio de Patologia Oral. Salvador, BA, Brasil
Abstract: Objective Dental granulomas (DGs) and radicular cysts (RCs) are chronic periapical lesions frequently involving the jaws. Langerhans cells (LCs) are dendritic cells responsible for the presentation of antigens to T lymphocytes. This study examined the expression of LCs in DG and RCs by immunohistochemical staining. Study Design Eighteen cases of DGs and 26 cases of RCs were analyzed using anti-CD1a marker. Results CD1a-labeled LCs were observed in 11.1% of DGs and in 69.2% of RCs, showing a significant correlation (P < 0.0001; Fisher’s test). In DGs, LCs were only observed in granulation tissue, showing discrete immunostaining density. In RCs, LCs exhibited both a round and a dendritic shape in all epithelial layers. Although a correlation was observed between immunostaining density and epithelial thickness, as well as between immunostaining and inflammatory intensity, the differences were not significant in radicular cysts.
Keywords: Radicular cyst
Dental granuloma
Immunohistochemistry
Langerhans cell
DeCS: Células de Langerhans/imunologia
Granuloma Periapical/imunologia
Cisto Radicular/imunologia
Adolescente
Adulto
Idoso
Antígenos CD1/imunologia
Criança
Pré-Escolar
Femenino
Humanos
Imuno-Histoquímica
Masculino
Meia-Idade
Granuloma Periapical/patologia
Cisto Radicular/patologia
Issue Date: 2007
Publisher: Springer Verlag
Citation: SANTOS, L. C. et al. Immunohistochemical detection of Langerhans cells in dental granulomas and radicular cysts. Journal of Molecular Histology, v. 38, n. 3, p. 201-205, 2007.
DOI: 10.1007/s10735-007-9088-3
ISSN: 1567-2379
Copyright: open access
Appears in Collections:CPqGM - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Santos L C S Immunohistochemical....pdf199.68 kBAdobe PDFView/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.