Author | Lizcano, Omaira Vera | |
Author | Resende, Sarah Stela | |
Author | Melo, Yonne Francis Chehuan | |
Author | Lacerda, Marcus Vinicius Guimarães de | |
Author | Brito, Cristiana Ferreira Alves de | |
Author | Zalis, Mariano Gustavo | |
Access date | 2015-04-28T16:54:53Z | |
Available date | 2015-04-28T16:54:53Z | |
Document date | 2014 | |
Citation | LIZCANO, Omaira Vera et al. Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon. Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 109, n. 7, p. 948-951, 2014 | pt_BR |
ISSN | 0074-0276 | |
URI | https://www.arca.fiocruz.br/handle/icict/10133 | |
Sponsorship | CAPES, FAPEAM, CNPq | pt_BR |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz | pt_BR |
Rights | open access | pt_BR |
Title | Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/0074-0276140241 | |
Abstract | The molecular basis of Plasmodium vivax chloroquine (CQ) resistance is still unknown. Elucidating the mo¬lecular background of parasites that are sensitive or resistant to CQ will help to identify and monitor the spread of resistance. By genotyping a panel of molecular markers, we demonstrate a similar genetic variability between in vitro CQ-resistant and sensitive phenotypes of P. vivax parasites. However, our studies identified two loci (MS8 and MSP1-B10) that could be used to discriminate between both CQ-susceptible phenotypes among P. vivax iso¬lates in vitro. These preliminary data suggest that microsatellites may be used to identify and to monitor the spread of P. vivax-resistance around the world. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Serviço de Patologia Clínica. Laboratório de Infectologia e Parasitologia Molecular. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brasil | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Serviço de Patologia Clínica. Laboratório de Infectologia e Parasitologia Molecular. Rio de Janeiro, RJ, Brasil | pt_BR |
Subject | Plasmodium vivax | pt_BR |
Subject | chloroquine | pt_BR |
Subject | resistance | pt_BR |