Author | Soares, Milena Botelho Pereira | |
Author | Macambira, Simone Garcia | |
Author | Carvalho, Antonio Carlos Campos de | |
Author | Santos, Ricardo Ribeiro dos | |
Access date | 2015-04-17T17:22:31Z | |
Available date | 2015-04-17T17:22:31Z | |
Document date | 2007 | |
Citation | SOARES, M. B. P. et al. Cellular therapy in Chagas' disease: potential applications in patients with chronic cardiomyopathy. Regenerative Medicine, v. 2, n. 3, p. 257-264, 2007. | pt_BR |
ISSN | 1746-076X | |
URI | https://www.arca.fiocruz.br/handle/icict/10078 | |
Language | eng | pt_BR |
Publisher | Future Medicine | pt_BR |
Rights | open access | pt_BR |
Title | Cellular therapy in Chagas' disease: potential applications in patients with chronic cardiomyopathy. | pt_BR |
Type | Article | pt_BR |
DOI | 10.2217/17460751.2.3.257 | |
Abstract | Nearly a century after its discovery, Chagas' disease, caused by the protozoan Trypanosoma cruzi, remains a major health problem in Latin America. Although efforts in transmission control have contributed to a decrease in the number of new cases, approximately a third of chronic Chagasic individuals have or will develop the symptomatic forms of the disease, mainly cardiomyopathy. Chagas' disease is a progressively debilitating disease, which, at the final stages, there are no currently available treatments other than heart transplantation. In this scenario, cellular therapy is being tested as an alternative for millions of patients with heart dysfunction due to Chagas' disease. In this article, we review the studies of cellular therapy in animal models and in patients with Chagasic cardiomyopathy and the possible mechanisms by which cellular therapy may act in this disease. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Cardiologia de Laranjeiras. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, Brasil | pt_BR |
Subject | Cardiomyopathy | pt_BR |
Subject | Cellular therapy | pt_BR |
Subject | Chagas disease | pt_BR |
Subject | Fibrosis | pt_BR |
Subject | Inflammation | pt_BR |
Subject | Stem cells | pt_BR |
DeCS | Cardiomiopatias/terapia | pt_BR |
DeCS | Transplante de Células/métodos | pt_BR |
DeCS | Transplante de Células/tendências | pt_BR |
DeCS | Doença de Chagas/terapia | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Transplante de Medula Óssea/métodos | pt_BR |
DeCS | Cardiomiopatias/quimioterapia | pt_BR |
DeCS | Transplante de Células/patologia | pt_BR |
DeCS | Doença de Chagas/quimioterapia | pt_BR |
DeCS | Doença Crônica | pt_BR |
DeCS | Modelos Animais de Doenças | pt_BR |
DeCS | Humanos | pt_BR |